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Abstract
The gut microbiome and its link with human health and disease have gained a lot of attention recently. The microbiome executes its functions in the host by carrying out the transformation of dietary components and/or de novo synthesis of various essential nutrients. The presence of complex microbial communities makes it difficult to understand the host-microbiome interplay in the metabolism of dietary components. This review attempts to uncover the incredible role of the gut microbiome in the metabolism of dietary components, diet-microbiome interplay, and restoration of the microbiome. The in silico analysis performed in this study elucidates the functional description of essential/hub genes involved in the amino acid degradation pathway, which are mutually present in the host and its gut microbiome. Hence, the computational model helps comprehend the inter-and intracellular molecular networks between humans and their microbial partners.
Acknowledgments
JS thankfully acknowledge SERB project and GSK thankfully acknowledge DST-SYST grant. PR thankfully acknowledges the NPDF scheme (Sanction No. PDF/2019/002762/Dated:23/12/2019) under DST-SERB, New Delhi, India.
Disclosure statement
No potential conflict of interest was reported by the authors.
Authors' contributions
R.R., PSS, and P.R., performed the analysis and preparation of draft; GSK and PKJ guided preparation of the manuscript; and J.S. guided literature review and analysis.