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Dietary polysaccharides exert biological functions via epigenetic regulations: Advance and prospectives

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Pages 114-124 | Published online: 06 Jul 2021
 

Abstract

Bioactive substances derived from natural products are valued for effective health-related activities. As extremely important component of plants, animal cell membrane and microbes cytoderm, polysaccharides have been applied as medications, foods and cosmetics stemming from their prominent biological functions and minor side-effects. Recent studies indicate that polysaccharides exert biological effects also through epigenetic mechanism. Through the intervention of DNA methylation, histone modification, and non-coding RNA, polysaccharides participatate in regulation of immunity/inflammation, glucose and lipid metabolism, antioxidant damage and anti-tumor, which presents novel mechanism of polysaccharide exerting various functions. In this review, the latest advances in the biological functions of dietary polysaccharides via epigenetic regulations were comprehensively summarized and discussed. From the view point of epigenetic regulation, investigating the relationship between polysaccharides and biological effects will enhance our understandings of polysaccharides and also means huge breakthrough of molecular mechanism in the polysaccharide research fields. The paper will provide important reference to these investigators of polysaccharide research and expand the applications of dietary polysaccharides in the functional food developments.

Disclosure statement

The authors declare that they have no competing financial interests.

Additional information

Funding

This work was supported by the Program for Science & Technology Innovation Platform of Hunan Province (2019TP1029); Natural Science Foundation of Hunan Province (2018JJ2672); and Graduate Innovative Research Project of Hunan province and Central South University of Forestry and Technology (CX20200704, CX20201017).

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