Dietary polysaccharides exert biological functions via epigenetic regulations: Advance and prospectives

References

• Ayissi, V. B., A. Ebrahimi, and H. Schluesenner. 2014. Epigenetic effects of natural polyphenols: a focus on SIRT1-mediated mechanisms. Molecular Nutrition & Food Research 58 (1):22–32. 10.1002/mnfr.201300195.
   PubMed Web of Science ®Google Scholar
• Chen, H. L., H. L. Tan, J. Yang, Y. Y. Wei, and T. J. Hu. 2018. Sargassum polysaccharide inhibits inflammatory response in PCV2 infected-RAW264.7 cells by regulating histone acetylation. Carbohydrate Polymers 200:633–40. doi: 10.1016/j.carbpol.2018.06.060.
   PubMed Web of Science ®Google Scholar
• Chen, X., L. Yuan, J. Du, C. Zhang, and H. Sun. 2019. The polysaccharide from the roots of Actinidia eriantha activates RAW264.7 macrophages via regulating microRNA expression. International Journal of Biological Macromolecules 132:203–12. doi: 10.1016/j.ijbiomac.2019.03.158.
   PubMed Web of Science ®Google Scholar
• Chu, Y., Y. Fang, J. Chi, J. Li, D. Zhang, Y. Zou, and Z. Wang. 2018. Astragalus polysaccharides decrease proliferation, migration, and invasion but increase apoptosis of human osteosarcoma cells by up-regulation of microRNA-133a. Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas 51 (12):e7665. doi: 10.1590/1414-431X20187665.
   PubMed Web of Science ®Google Scholar
• Cuevas-Sierra, A., O. Ramos-Lopez, J. I. Riezu-Boj, F. I. Milagro, and J. A. Martinez. 2019. Diet, gut microbiota, and obesity: Links with host genetics and epigenetics and potential applications. Advances in Nutrition (Bethesda, Md.) 10 (suppl_1):S17–S30. doi: 10.1093/advances/nmy078.
   PubMed Web of Science ®Google Scholar
• da Silva, T. F., S. N. Casarotti, G. L. V. de Oliveira, and A. L. B. Penna. 2021. The impact of probiotics, prebiotics, and synbiotics on the biochemical, clinical, and immunological markers, as well as on the gut microbiota of obese hosts. Critical Reviews in Food Science and Nutrition 61 (2):337–55. doi: 10.1080/10408398.2020.1733483.
   PubMed Web of Science ®Google Scholar
• Deng, W., X. Cao, Y. Wang, Q. Yu, Z. Zhang, R. Qu, J. Chen, G. Shao, X. Gao, X. Xu, et al. 2016. Pleurotus eryngii polysaccharide promotes pluripotent reprogramming via facilitating epigenetic modification. Journal of Agricultural and Food Chemistry 64 (6):1264–73. doi: 10.1021/acs.jafc.5b05661.
   PubMed Web of Science ®Google Scholar
• Do, M. H., H. B. Lee, M. J. Oh, H. Jhun, S. Y. Choi, and H. Y. Park. 2021. Polysaccharide fraction from greens of Raphanus sativus alleviates high fat diet-induced obesity. Food Chemistry 343:128395. doi: 10.1016/j.foodchem.2020.128395.
   PubMed Web of Science ®Google Scholar
• Esteller, M. 2011. Non-coding RNAs in human disease. Nature Reviews. Genetics 12 (12):861–74. doi: 10.1038/nrg3074.
   PubMed Web of Science ®Google Scholar
• Feng, B., Y. Zhu, Z. Su, L. Tang, C. Sun, C. Li, and G. Zheng. 2018. Basil polysaccharide attenuates hepatocellular carcinoma metastasis in rat by suppressing H3K9me2 histone methylation under hepatic artery ligation-induced hypoxia. International Journal of Biological Macromolecules 107 (Pt B):2171–9. doi: 10.1016/j.ijbiomac.2017.10.088.
   PubMedGoogle Scholar
• Guo, T., F. Luo, and Q. Lin. 2020. You are affected by what your parents eat: Diet, epigenetics, transgeneration and intergeneration. Trends in Food Science & Technology 100:248–61. doi: 10.1016/j.tifs.2020.04.021.
   Web of Science ®Google Scholar
• Chen, H. L., H. L. Tan, J. Yang, M. Song, H. Feng, N. Kuang, W. Y. Hu, S. Y. Chen, Y. Y. Wei, and T. J. Hu. 2019. Inhibitory effect of polysaccharide of Sargassum weizhouense on PCV2 induced inflammation in mice by suppressing histone acetylation. Biomedicine & Pharmacotherapy 112:108741. doi: 10.1016/j.biopha.2019.108741.
   PubMed Web of Science ®Google Scholar
• Hardy, T. M., and T. O. Tollefsbol. 2011. Epigenetic diet: Impact on the epigenome and cancer. Epigenomics 3 (4):503–18. doi: 10.2217/epi.11.71.
   PubMed Web of Science ®Google Scholar
• Huang, D., L. Cui, S. Ahmed, F. Zainab, Q. Wu, X. Wang, and Z. Yuan. 2019. An overview of epigenetic agents and natural nutrition products targeting DNA methyltransferase, histone deacetylases and microRNAs. Food and Chemical Toxicology 123:574–94. doi: 10.1016/j.fct.2018.10.052.
   PubMed Web of Science ®Google Scholar
• Huang, Y. C., H. J. Tsay, M. K. Lu, C. H. Lin, C. W. Yeh, H. K. Liu, and Y. J. Shiao. 2017. Astragalus membranaceus polysaccharides ameliorates obesity, hepatic steatosis, neuroinflammation and cognition impairment without affecting amyloid deposition in metabolically stressed APPswe/PS1dE9 mice. International Journal of Molecular Sciences 18 (12):2746. doi: 10.3390/ijms18122746.
   PubMed Web of Science ®Google Scholar
• Humphreys, K. J., M. A. Conlon, G. P. Young, D. L. Topping, Y. Hu, J. M. Winter, A. R. Bird, L. Cobiac, N. A. Kennedy, M. Z. Michael, et al. 2014. Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: A randomized trial. Cancer Prevention Research (Philadelphia, Pa.) 7 (8):786–95. doi: 10.1158/1940-6207.CAPR-14-0053.
   PubMed Web of Science ®Google Scholar
• Inoue, S., K. Honma, K. Mochizuki, and T. Goda. 2015. Induction of histone H3K4 methylation at the promoter, enhancer, and transcribed regions of the Si and Sglt1 genes in rat jejunum in response to a high-starch/low-fat diet. Nutrition (Burbank, Los Angeles County, Calif.) 31 (2):366–72. doi: 10.1016/j.nut.2014.07.017.
   PubMed Web of Science ®Google Scholar
• Inoue, S., K. Mochizuki, and T. Goda. 2011. Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes. Journal of Nutritional Science and Vitaminology 57 (2):162–9. doi: 10.3177/jnsv.57.162.
   PubMed Web of Science ®Google Scholar
• Kim, E. H., S. W. Kim, S. J. Park, S. Kim, K. M. Yu, S. G. Kim, S. H. Lee, Y. K. Seo, N. H. Cho, K. Kang, et al. 2019. Greater efficacy of black Ginseng (CJ EnerG) over red Ginseng against lethal influenza A virus infection. Nutrients 11 (8):1879. doi: 10.3390/nu11081879.
   PubMed Web of Science ®Google Scholar
• Lawrence, M., S. Daujat, and R. Schneider. 2016. Lateral thinking: How histone modifications regulate gene expression. Trends in Genetics: TIG 32 (1):42–56. doi: 10.1016/j.tig.2015.10.007.
   PubMed Web of Science ®Google Scholar
• Le, X., P. Luo, Y. Gu, Y. Tao, and H. Liu. 2015. Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice. Iranian Journal of Basic Medical Sciences 18 (8):827–31. doi: 10.1109/IROS.2015.7353796.
   PubMed Web of Science ®Google Scholar
• Liang, W., and Z. Yue. 2019. Lycium barbarum polysaccharides promote osteoblasts viability by regulating microRNA-17/PTEN. Life Sciences 225:72–8. doi: 10.1016/j.lfs.2019.04.001.
   PubMed Web of Science ®Google Scholar
• Li, Y., X. Lei, W. Guo, S. Wu, Y. Duan, X. Yang, and X. Yang. 2018. Transgenerational endotoxin tolerance-like effect caused by paternal dietary Astragalus polysaccharides in broilers' jejunum. International Journal of Biological Macromolecules 111:769–79. doi: 10.1016/j.ijbiomac.2018.01.095.
   PubMed Web of Science ®Google Scholar
• Ling, C., and T. Rönn. 2019. Epigenetics in human obesity and type 2 diabetes. Cell Metabolism 29 (5):1028–44. doi: 10.1016/j.cmet.2019.03.009.
   PubMed Web of Science ®Google Scholar
• Lin, G. P., D. S. Wu, X. W. Xiao, Q. Y. Huang, H. B. Chen, D. Liu, H. Q. Fu, X. H. Chen, and C. Zhao. 2020. Structural characterization and antioxidant effect of green alga Enteromorpha prolifera polysaccharide in Caenorhabditis elegans via modulation of microRNAs. International Journal of Biological Macromolecules 150:1084–92. doi: 10.1016/j.ijbiomac.2019.10.114.
   PubMed Web of Science ®Google Scholar
• Li, A., X. Shuai, Z. Jia, H. Li, X. Liang, D. Su, and W. Guo. 2015. Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b. Journal of Translational Medicine 13:100. doi: 10.1186/s12967-015-0465-5.
   PubMed Web of Science ®Google Scholar
• Liu, Y., B. Upadhyaya, A. R. Fardin-Kia, R. M. Juenemann, and M. Dey. 2016. Dietary resistant starch type 4-derived butyrate attenuates nuclear factor-kappa-B1 through modulation of histone H3 trimethylation at lysine 27. Food & Function 7 (9):3772–81. doi: 10.1039/c6fo00856a.
   PubMed Web of Science ®Google Scholar
• Liu, Y., and Y. Zhang. 2019. Lycium barbarum polysaccharides alleviate hydrogen peroxide-induced injury by up-regulation of miR-4295 in human trabecular meshwork cells. Experimental and Molecular Pathology 106:109–15. doi: 10.1016/j.yexmp.2018.12.007.
   PubMed Web of Science ®Google Scholar
• Li, B., P. Wu, W. Fu, Y. Xiong, L. Zhang, Y. Gao, G. Deng, S. Zong, and G. Zeng. 2019. The role and mechanism of miRNA-1224 in the polygonatum sibiricum polysaccharide regulation of bone marrow-derived macrophages to osteoclast differentiation. Rejuvenation Res 22 (5):420–30. doi: 10.1089/rej.2018.2126.
   PubMed Web of Science ®Google Scholar
• Li, C., X. Wu, H. Zhang, G. Yang, M. Hao, S. Sheng, Y. Sun, J. Long, C. Hu, X. Sun, et al. 2015. A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway. Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 36 (8):6285–93. doi: 10.1007/s13277-015-3314-5.
   PubMedGoogle Scholar
• Li, R., F. Yin, Y. Guo, Q. Ruan, and Q. Zhu. 2018. Angelica polysaccharide protects PC-12 cells from lipopolysaccharide-induced injury via down-regulating microRNA-223. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 108:1320–7. doi: 10.1016/j.biopha.2018.09.147.
   PubMed Web of Science ®Google Scholar
• Li, Q., Z. Zhang, H. Li, X. Pan, S. Chen, Z. Cui, J. Ma, Z. Zhou, and B. Xing. 2019. Lycium barbarum polysaccharides protects H9c2 cells from hypoxia-induced injury by down-regulation of miR-122. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 110:20–8. doi: 10.1016/j.biopha.2018.11.012.
   PubMed Web of Science ®Google Scholar
• Malcomson, F. C., N. D. Willis, I. McCallum, L. Xie, B. Lagerwaard, S. Kelly, D. M. Bradburn, N. J. Belshaw, I. T. Johnson, and J. C. Mathers. 2017. Non-digestible carbohydrates supplementation increases miR-32 expression in the healthy human colorectal epithelium: A randomized controlled trial. Molecular Carcinogenesis 56 (9):2104–11. doi: 10.1002/mc.22666.
   PubMed Web of Science ®Google Scholar
• Miranda, K. C., T. Huynh, Y. Tay, Y. S. Ang, W. L. Tam, A. M. Thomson, B. Lim, and I. Rigoutsos. 2006. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 126 (6):1203–17. doi: 10.1016/j.cell.2006.07.031.
   PubMed Web of Science ®Google Scholar
• Moore, L. D., T. Le, and G. Fan. 2013. DNA methylation and its basic function. Neuropsychopharmacology : official Publication of the American College of Neuropsychopharmacology 38 (1):23–38. doi: 10.1038/npp.2012.112.
   PubMed Web of Science ®Google Scholar
• Nielsen, T. S., Z. Bendiks, B. Thomsen, M. E. Wright, P. K. Theil, B. L. Scherer, and M. L. Marco. 2019. High-amylose maize, potato, and butyrylated starch modulate large intestinal fermentation, microbial composition, and oncogenic miRNA expression in rats fed a high-protein meat diet. International Journal of Molecular Sciences 20 (9):2137. doi: 10.3390/ijms20092137.
   PubMed Web of Science ®Google Scholar
• Niu, T., L. Jin, S. Niu, C. Gong, and H. Wang. 2018. Lycium Barbarum polysaccharides alleviates oxidative damage induced by H2O2 through down-regulating microRNA-194 in PC-12 and SH-SY5Y cells. Cellular Physiology and Biochemistry : international Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology 50 (2):460–72. doi: 10.1159/000494159.
   PubMedGoogle Scholar
• Pan, H., and L. Zhu. 2018. Angelica sinensis polysaccharide protects rat cardiomyocytes H9c2 from hypoxia-induced injury by down-regulation of microRNA-22. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 106:225–31. doi: 10.1016/j.biopha.2018.06.120.
   PubMed Web of Science ®Google Scholar
• Qian, H. F., Y. Li, and L. Wang. 2017. Vaccinium bracteatum Thunb. leaves' polysaccharide alleviates hepatic gluconeogenesis via the downregulation of miR-137. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 95:1397–403. doi: 10.1016/j.biopha.2017.09.040.
   PubMed Web of Science ®Google Scholar
• Ren, Q., S. Zhao, C. Ren, and Z. Ma. 2018. Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblasts. International Journal of Immunopathology and Pharmacology 31:205873841875918. doi: 10.1177/2058738418759180.
   Web of Science ®Google Scholar
• Ruan, Y., H. Li, L. Pu, T. Shen, and Z. Jin. 2018. Tremella fuciformis polysaccharides attenuate oxidative stress and inflammation in macrophages through miR-155. Analytical Cellular Pathology (Amsterdam) 2018:5762371. doi: 10.1155/2018/5762371.
   PubMedGoogle Scholar
• Sang, T., C. Guo, D. Guo, J. Wu, Y. Wang, Y. Wang, J. Chen, C. Chen, K. Wu, K. Na, et al. 2021. Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation. Carbohydrate polymers 256:117594. doi: 10.1016/j.carbpol.2020.117594.
   PubMed Web of Science ®Google Scholar
• Shen, J., H. S. Park, Y. M. Xia, G. S. Kim, and S. W. Cui. 2014. The polysaccharides from fermented Ganoderma lucidum mycelia induced miRNAs regulation in suppressed HepG2 cells. Carbohydrate Polymers 103:319–24. doi: 10.1016/j.carbpol.2013.12.044.
   PubMed Web of Science ®Google Scholar
• Shimada, M., K. Mochizuki, and T. Goda. 2009a. Dietary resistant starch reduces histone acetylation on the glucose-dependent insulinotropic polypeptide gene in the jejunum. Bioscience, Biotechnology, and Biochemistry 73 (12):2754–7. doi: 10.1271/bbb.90384.
   PubMed Web of Science ®Google Scholar
• Shimada, M., K. Mochizuki, and T. Goda. 2009b. Feeding rats dietary resistant starch shifts the peak of SGLT1 gene expression and histone H3 acetylation on the gene from the upper jejunum toward the ileum. Journal of Agricultural and Food Chemistry 57 (17):8049–55. doi: 10.1021/jf900594z.
   PubMed Web of Science ®Google Scholar
• Shimada, M., K. Mochizuki, and T. Goda. 2011. Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp gene in the jejunum. Journal of Agricultural and Food Chemistry 59 (4):1464–9. doi: 10.1021/jf103111u.
   PubMed Web of Science ®Google Scholar
• Sun, J., J. Xiong, L. Yao, T. Chen, J. Luo, Q. Xi, and Y. Zhang. 2019. The effect of dietary ginseng polysaccharide supplementation on porcine milk-derived esRNAs involved in the host immune responses. Journal of Animal Physiology and Animal Nutrition 103 (1):276–82. doi: 10.1111/jpn.12993.
   PubMed Web of Science ®Google Scholar
• Sun, J., W. Liang, X. Yang, Q. Li, and G. Zhang. 2019. Cytoprotective effects of galacto-oligosaccharides on colon epithelial cells via up-regulating miR-19b. Life Sciences 231:116589. doi: 10.1016/j.lfs.2019.116589.
   PubMed Web of Science ®Google Scholar
• Sun, Q., S. Huang, X. Wang, Y. Zhu, Z. Chen, and D. Chen. 2015. N6-methyladenine functions as a potential epigenetic mark in eukaryotes. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology 37 (11):1155–62. doi: 10.1002/bies.201500076.
   PubMed Web of Science ®Google Scholar
• Wang, N., J. Liu, F. Xie, X. Gao, J. H. Ye, L. Y. Sun, R. Wei, and J. Ai. 2015. miR-124/ATF-6, a novel lifespan extension pathway of Astragalus polysaccharide in Caenorhabditis elegans. Journal of Cellular Biochemistry 116 (2):242–51. doi: 10.1002/jcb.24961.
   PubMed Web of Science ®Google Scholar
• Wang, P. C., S. Zhao, B. Y. Yang, Q. H. Wang, and H. X. Kuang. 2016. Anti-diabetic polysaccharides from natural sources: A review. Carbohydrate Polymers 148:86–97. doi: 10.1016/j.carbpol.2016.02.060.
   PubMed Web of Science ®Google Scholar
• Wang, X., W. Wang, L. Wang, C. Yu, G. Zhang, H. Zhu, C. Wang, S. Zhao, C. A. Hu, and Y. Liu. 2019. Lentinan modulates intestinal microbiota and enhances barrier integrity in a piglet model challenged with lipopolysaccharide. Food & Function 10 (1):479–89. doi: 10.1039/c8fo02438c.
   PubMed Web of Science ®Google Scholar
• Wei, Z., S. Weng, L. Wang, and Z. Mao. 2018. Mechanism of Astragalus polysaccharides in attenuating insulin resistance in Rats with type 2 diabetes mellitus via the regulation of liver microRNA-203a-3p. Molecular Medicine Reports 17 (1):1617–24. doi: 10.3892/mmr.2017.8084.
   PubMed Web of Science ®Google Scholar
• Wu, S., X. Ren, Y. Li, W. Guo, X. Lei, J. Yao, and X. Yang. 2017. Effect of dietary Astragalus Polysaccharide supplements on testicular miRNA expression profiles and enzymatic changes of breeder cocks. Scientific Reports 7 (1):38864. doi: 10.1038/srep38864.
   PubMedGoogle Scholar
• Xiao, C., Q. Wu, Y. Xie, J. Tan, Y. Ding, and L. Bai. 2018. Hypoglycemic mechanisms of Ganoderma lucidum polysaccharides F31 in db/db mice via RNA-seq and iTRAQ. Food & Function 9 (12):6495–507. doi: 10.1039/c8fo01656a.
   PubMed Web of Science ®Google Scholar
• Yang, J., H. L. Tan, L. Y. Gu, M. L. Song, Y. Y. Wu, J. B. Peng, Z. B. Lan, Y. Y. Wei, and T. J. Hu. 2017. Sophora subprosrate polysaccharide inhibited cytokine/chemokine secretion via suppression of histone acetylation modification and NF-κB activation in PCV2 infected swine alveolar macrophage. International Journal of Biological Macromolecules 104 (Pt A):900–8. doi: 10.1016/j.ijbiomac.2017.06.102.
   PubMedGoogle Scholar
• Yang, J., X. Shao, J. Jiang, Y. Sun, L. Wang, and L. Sun. 2018. Angelica sinensis polysaccharide inhibits proliferation, migration, and invasion by downregulating microRNA-675 in human neuroblastoma cell line SH-SY5Y. Cell Biology International 42 (7):867–76. doi: 10.1002/cbin.10954.
   PubMed Web of Science ®Google Scholar
• Yang, K., Y. W. Li, Z. Y. Gao, W. Xiao, T. Q. Li, W. Song, J. Zheng, H. Chen, G. H. Chen, and H. Y. Zou. 2019. MiR-93 functions as a tumor promoter in prostate cancer by targeting disabled homolog 2 (DAB2) and an antitumor polysaccharide from green tea (Camellia sinensis) on their expression. International Journal of Biological Macromolecules 125:557–65. doi: 10.1016/j.ijbiomac.2018.12.088.
   PubMed Web of Science ®Google Scholar
• Yang, K., Z. Y. Gao, T. Q. Li, W. Song, W. Xiao, J. Zheng, H. Chen, G. H. Chen, and H. Y. Zou. 2019. Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer. International Journal of Biological Macromolecules 122:95–103. doi: 10.1016/j.ijbiomac.2018.10.101.
   PubMed Web of Science ®Google Scholar
• Yang, Z., J. Zhao, J. Wang, J. Li, K. Ouyang, and W. Wang. 2019. Effects of Cyclocarya paliurus polysaccharide on lipid metabolism-related genes DNA methylation in rats. International Journal of Biological Macromolecules 123:343–9. doi: 10.1016/j.ijbiomac.2018.11.110.
   PubMed Web of Science ®Google Scholar
• Yu, Y., M. Shen, Q. Song, and J. Xie. 2018. Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review. Carbohydrate Polymers 183:91–101. doi: 10.1016/j.carbpol.2017.12.009.
   PubMed Web of Science ®Google Scholar
• Zhang, R., Y. Xu, H. Niu, T. Tao, T. Ban, L. Zheng, and J. Ai. 2018. Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA-1. Journal of Cellular and Molecular Medicine 22 (10):4830–9. doi: 10.1111/jcmm.13740.
   PubMed Web of Science ®Google Scholar
• Zhang, S., and Y. Zhao. 2019. Lentinan protects cardiomyocytes against hypoxia-induced injury by regulation of microRNA-22/Sirt1. Artificial Cells, Nanomedicine, and Biotechnology 47 (1):3938–46. doi: 10.1080/21691401.2019.1666863.
   PubMed Web of Science ®Google Scholar
• Zhang, T., S. Cooper, and N. Brockdorff. 2015. The interplay of histone modifications - writers that read. EMBO Reports 16 (11):1467–81. doi: 10.15252/embr.201540945.
   PubMed Web of Science ®Google Scholar
• Zheng, Z., and B. Zhao. 2018. Astragalus polysaccharide protects hypoxia-induced injury by up-regulation of miR-138 in rat neural stem cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 102:295–301. doi: 10.1016/j.biopha.2018.03.040.
   PubMed Web of Science ®Google Scholar
• Zhou, L., Z. Liu, Z. Wang, S. Yu, T. Long, X. Zhou, and Y. Bao. 2017. Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo. Scientific Reports 7:44822. doi: 10.1038/srep44822.
   PubMed Web of Science ®Google Scholar
• Zong, A., H. Z. Cao, and F. S. Wang. 2012. Anticancer polysaccharides from natural resources: a review of recent research. Carbohydrate Polymers 90 (4):1395–410. doi: 10.1016/j.carbpol.2012.07.026
   PubMed Web of Science ®Google Scholar