Health functions and related molecular mechanisms of ellagitannin-derived urolithins

Abstract

Ellagitannins are vital bioactive polyphenols that are widely distributed in a variety of plant-based foods. The main metabolites of ellagitannins are urolithins, and current research suggests that urolithins provide a variety of health benefits. This review focused on the role of the gut bacteria in the conversion of ellagitannins to urolithins. Based on the results of in vitro and in vivo studies, the health benefits of urolithins, including antioxidant, anti-inflammatory, anti-cancer, anti-obesity, anti-diabetic, anti-aging, cardiovascular protective, neuroprotective, kidney protective, and muscle mass protective effects, were thoroughly outlined, with a focus on their associated molecular mechanisms. Finally, we briefly commented on urolithins’ safety. Overall, urolithins’ diverse health benefits indicate the potential utilization of ellagitannins and urolithins in the creation of functional foods and nutraceuticals to treat and prevent some chronic diseases.

Graphical abstract

Keywords:

• Urolithins
• gut metabolites
• cancer
• inflammation
• ellagitannins

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

GRG would like to express his gratitude to the Rajagiri College of Social Sciences (Autonomous), Kalamaserry, Kochi, Kerala, India, for providing complete research support.