Advanced review on type II collagen and peptide: preparation, functional activities and food industry application

Abstract

Type II collagen is a homologous super-helical structure consisting of three identical α1(II) chains. It is a major component of animal cartilage, and is widely used in the food industry. Type II collagen can be extracted by acids, salts, enzymes, and via auxiliary methods and can be further hydrolyzed chemically and enzymatically to produce collagen peptides. Recent studies have shown that type II collagen and its polypeptides have good self-assembly properties and important biological activities, such as maintaining cartilage tissue integrity, inducing immune tolerance, stimulating chondrocyte growth and redifferentiation, and providing antioxidant benefits. This review focuses specifically on type II collagen and describes its structure, extraction, and purification, as well as the preparation of type II collagen peptides. In particular, the self-assembly properties and functional activities of type II collagen and collagen peptides are reviewed. In addition, recent research advances in the application of type II collagen and collagen peptides in functional foods, food additives, food coating materials, edible films, and carriers for the food industry are presented. This paper provides more detailed and comprehensive information on type II collagen and peptide for their application.

Keywords:

• Type II collagen
• peptide
• functional activity
• health benefit
• food industry application

Disclosure statement

The authors declare that there are no conflicts of interest.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 32272473 & 31972104) and Natural Science Foundation of Zhejiang Province (No. LR23C200003). We are encouraged by funding support from Meitek Technology Co., Ltd.