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Articles

NaBr mediated regioselective synthesis of 3-Selanylindoles

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Pages 394-399 | Received 15 Oct 2017, Accepted 02 Jan 2018, Published online: 23 Jan 2018
 

GRAPHICAL ABSTRACT

ABSTRACT

A convenient NaBr mediated procedure is developed for the preparation of 3-selanylindoles from indoles and diselenides. In this protocol, NaBr is first oxidized by mCPBA into molecular bromine, which reacts with diselenide to form RSeBr. The in situ generated active electrophilic selenium species, then reacts with indoles, affording a series of 3-selanylindoles with high regioselectivity and in moderate to good yields.

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