Abstract
The present paper discusses the coinage metal-catalyzed cycloisomerization reaction of phosphorylated 3-(α- or β-hydroxyalkyl)allenes. 3-(α- or β-Hydroxyalkyl)-allenylphosphonates and -allenyl phosphine oxides were smoothly converted into the 2-phosphoryl-2,5-dihydrofurans or 2-phosphoryl-5,6-dihydro-2Н-pyrans by using 5 mol % of coinage metal salts as catalyst in 5-endo-trig or 6-endo-trig cycloisomerization, respectively. Experimental conditions such as the type of the solvent, the reaction temperature, the mol % and the type of the catalyst and its influence on the yields and the reaction time of the cycloisomerization reaction of the phosphorylated 3-(α- or β-hydroxyalkyl)allenes were optimized.
Disclosure statement
No potential conflict of interest was reported by the authors.