Nano catalytic synthesis of flavanone phosphonates using domino Knoevenagel-phospha-Michael route

Abstract

Novel derivatives of diethyl (4-oxo-2-phenylchroman-3-yl) methyl phosphonate have been synthesized under optimal conditions using domino-Knoevenagel-phospha-Michael reaction catalyzed by nano-zinc oxide. The combination of recovery and reusability of catalyst, simple and applicable approach, good reaction time and good yields of products make this method as a suitable route for this purpose. The structures of the products were determined by FT-IR, ¹H-, ¹³C- and ³¹P- Nuclear Magnetic Resonance spectroscopies, and elemental analysis.

GRAPHICAL ABSTRACT

Keywords:

• Flavanone phosphonates
• domino Knoevenagel-phospha-Michael
• nano zinc oxide

Acknowledgments

We gratefully acknowledge the financial support of this work by Marvdasht Islamic Azad University research council.

Disclosure statement

No potential conflict of interest was reported by the authors.