Development of a straightforward and efficient protocol for the one-pot multicomponent synthesis of substituted alpha-aminoallylphosphonates under catalyst-free condition

Abstract

A catalyst-free practical version of Kabachnik-Fields strategy has been developed for the efficient and straightforward one-pot synthesis of diversely substituted α-aminoallylphosphonates, a limitedly reported class of biologically important α-aminophosphonates family. The protocol offers many advantages including avoidance of additive/catalyst, one-pot multicomponent approach, operational simplicity, excellent regioselectivity, good to excellent yields, relatively short reaction-time, gram-scale applicability, high atom-economy and low E-factor.

Graphical Abstract

Keywords:

• α-aminoallylphosphonates
• catalyst-free
• regioselectivity
• one-pot MCR
• high atom-economy and low E-factor

Acknowledgements

The authors are thankful to the Department of Chemistry, Visva-Bharati for providing infrastructural facilities. IK is grateful to the UGC, New Delhi for awarding him Senior Research Fellowship.

Conflict of interest

There are no conflicts of interest to declare.

Additional information

Funding

This work was supported by University Grants Commission.