Ultrasound-assisted a domino three-component reaction to polycyclic selenopyrans synthesis

Abstract

A novel and efficient three-component reaction of substituted benzoyl chlorides, potassium selenocyanate and vinyl malononitriles was developed for the synthesis of polycyclic selenopyrans via an ultrasound-assisted domino vinylogous nucleophilic reaction/intramolecular selenocyclization/imine-enamine tautomerization reaction. Introducing a simple one-step method and use of available starting materials and mild reaction conditions are the most important advantages of this strategy.

Graphical Abstract

Keywords:

• Ultrasound
• domino reaction
• selenopyrans
• vinyl malononitriles
• Multicomponent reaction

Acknowledgments

We gratefully acknowledge the financial support from the Research Council of Shahid Beheshti University and the Iran National Science Foundation (INSF).

Disclosure statement

No potential conflict of interest was reported by the authors.