Synthesis and lipid-lowering effects of phospholipid-polyunsaturated fatty acids (PL-PUFA) in high fat diet induced obese mice

Abstract

In this study, phospholipid-polyunsaturated fatty acids (PL-PUFA), which was a glycerophosphamide analogue containing DHA/DPA of phospholipid derivative, was synthesized from algae oil in two steps. The compound of P1/P2 in the PL-PUFA was isolated through preparative HPLC with the contained of 70.24%, and 23.86%, respectively. Intragastric administration of 200 mg/kg PL-PUFA can strongly suppress net body weight gain and obesity-related hyperlipidemia. The net body-weight gain of treatment group was decreased 5.18% than that of the normal group. Serum TC levels of treatment group were significantly suppressed, and it was reduced by 55.95%. However, for HDL-C levels, none of the model group and treatment group showed significant differences comparing with the normal group. The preliminary biological data of PL-PUFA in this work strongly supports our belief that the analogue glycerophosphamide structure containing with ω-3 PUFAs is providing a beneficial effect on lowering serum lipids and TGs.

Graphical Abstract

Keywords:

• Synthesis
• lipid-lowering effects
• PL-PUFA
• high fat diet

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Science and Technology Project of Xiamen (3502Z20221036); Fujian Provincial Marine Economic Development Special Fund Project (FJHJF-L-2021-4).