Contemporary insights into the pathogenesis and treatment of chronic myeloproliferative neoplasms

Abstract

This review is based on the deliberations at the 5th John Goldman Colloquium held in Estoril on 2nd October 2015 and the 9th post-ASH International Workshop on chronic myeloid leukemia (CML) and BCR-ABL1-negative myeloproliferative neoplasms (MPN) which took place on the 10th–11th December 2014, immediately following the 56th American Society of Hematology Annual Meeting. It has been updated since and summarizes the most recent advances in the biology and therapy of these diseases, in particular updates of genetics of MPN, novel insights from mouse MPN models, targeting CML stem cells and its niche; clinical advances include updates on JAK2 inhibitors and other therapeutic approaches to BCR-ABL1-negative MPNs, the use of alpha interferons, updates on tyrosine kinase inhibitors (TKI) randomized trials in CML, TKI cessation studies, and optimal monitoring strategies.

Keywords:

• Molecular genetics
• myeloid leukemias and dysplasias
• stem and primitive progenitor cells

Acknowledgements

The 5th John Goldman Colloquium comprised of: Chair: R. Van Etten, Faculty – J. Radich, M. Mauro, T. Mughal, G. Saglio, J. Cortes; the 9^th Post-ASH CML-MPN workshop comprised of: Chairs: T Barbui, T Mughal; Faculty: O. Abdel-Wahab, G. Barosi, E. Chan, M. Deininger, C. Gambacorti-Passerini, O. Hantschel, R. Hehlmann, C. Jamieson, J.J. Kiladjian, S. Koschmieder, R. Kralovics, H.M. Kvasnicka, F. Mahon, G. Martinelli, R. Mesa, A. Mullaly, D. Perrotti, J. Prchal, F. Rasool, T. Odenike, H. Pahl, H. Gisslinger, M. Mauro, R. Rampal, G. Saglio, T. Shimoda, R. Silver, R. Skoda, T. Skorski, S. Soverini, J. Thiele, R. Tibes, R.A. Van Etten. The members wish to thank Dr. Alpa Parmar of Alpine Oncology Foundation, who helped organize both events; Alpine Oncology Foundation for supporting the 5th John Goldman CML Colloquium exclusively and Incyte Corporation and Bristol-Myers Squibb Oncology for support towards the 9th Post-ASH workshop. RVE was the recipient of the 2015 Janet Rowley Award.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org//10.1080/10428194.2016.1185783.