Organism-derived phthalate derivatives as bioactive natural products

Abstract

Phthalates are widely used in polymer materials as a plasticizer. These compounds possess potent toxic variations depending on their chemical structures. However, a growing body of evidence indicates that phthalate compounds are undoubtedly discovered in secondary metabolites of organisms, including plants, animals and microorganisms. This review firstly summarizes biological sources of various phthalates and their bioactivities reported during the past few decades as well as their environmental toxicities and public health risks. It suggests that these organisms are one of important sources of natural phthalates with diverse profiles of bioactivity and toxicity.

Keywords:

• Bioactivity
• natural product
• organism
• phthalate
• secondary metabolite

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Financial support from the National Key Research and Development Program of China [No. 2017YFE0103100], the National Natural Science Foundation of China [Nos. 41776139 and 81773628] and the Zhejiang Provincial Natural Science Foundation of China [LY16H300007 and LY16H300008] were gratefully acknowledged.