Octreotide and Octreotide-derived delivery systems

Abstract

Pharmaceutical peptide Octreotide is a somatostatin analog with targeting and therapeutic abilities. Over the last decades, Octreotide has been developed and approved to treat acromegaly and neuroendocrine tumours, and Octreotide-based radioactive conjugates have been leveraged clinically to detect small neuroendocrine tumour sites. Meanwhile, variety of Octreotide-derived delivery strategies have been proposed and explored for tumour targeted therapeutics or diagnostics in preclinical or clinical settings. In this review, we especially focus on the preclinical development and applications of Octreotide-derived drug delivery systems, diagnostic nanosystems, therapeutic nanosystems and multifunctional nanosystems, we also briefly discuss challenges and prospects of these Octreotide-derived delivery systems.

Keywords:

• Octreotide
• tumour targeting
• drug delivery
• diagnostic nanosystems
• therapeutic nanosystems
• cancer therapy

Acknowledgements

We acknowledge the support by Chinese Academy of Engineering 2022-HZ-10-03.

Disclosure statement

The authors declare no conflict of interest.