Investigation of in-vitro biocompatibility and in-vivo biodegradability of AM series Mg alloys

ABSTRACT

In this study, in vitro/vivo biocompatibility experiments of Mg-Al-Mn alloy were carried out, and AM50 and AM60 alloys were used in the experiments. Immersion and potentiodynamic corrosion have been applied to these alloys in vitro. For biocompatibility, cytotoxicity test was performed. A total of 40 rats were used for the in-vivo experiment. AM series alloys were surgically placed in the femoral condyle as mini screws and monitored radiographically. AM alloys were removed together with the femur at the end of 7 weeks and further examined. After in-vivo application, the biodegradability level was successfully concluded with blood mineral analysis and urinalysis. In this study, the bioprocess of AM series Mg alloys with Al and Mn additions has been completed. As a result, the AM alloys used can be classified as biocompatible and biodegradable materials.

Graphical Abstract

KEYWORDS:

• Mg alloy
• in-vitro
• in-vivo
• biodegradability
• biomaterial
• biocompatibility

Acknowledgments

In this study, the authors thank the Hitit University Scientific Research Projects (BAP) unit. In addition, at the stage of living experiments implemented within the scope of the project, the Ethics Committee of Van Yuzuncu Yıl University obtained the permission numbered 2019/09.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Contribution Statement

In the preparation of this study, the authors; A.C. in the experiment, proof and report phases, B.C. at the stages of the experiment, linguistic, correspondence, writing, and proof; B.C. experiment, report, proof, and linguistic stages; T.S. in-vivo experiments and report; G.A.A. experiment and report phase; Y.S. proof and linguistic stages; L.E. in-vitro experiments and report phase; M.T.A. in-vivo experiments, have contributed.