Advanced search
Publication Cover
Free Radical Research Volume 41, 2007 - Issue 6
Submit an article Journal homepage
134
Views
20
CrossRef citations to date
0
Altmetric
Original

Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase

Kyoung Ah Kang Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, 690-756, South Korea
,
Rui Zhang Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, 690-756, South Korea
,
Mei Jing Piao Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, 690-756, South Korea
,
Kyoung Hwa Lee Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, 690-756, South Korea
,
Bum Joon Kim Department of Microbiology, Seoul National University College of Medicine, Cancer Research Institute, Seoul, 110-799, South Korea
,
So Young Kim Department of Neuroscience, College of Medicine, Ewha Womans University, Seoul, 110-783, South Korea
,
Hee Sun Kim Department of Neuroscience, College of Medicine, Ewha Womans University, Seoul, 110-783, South Korea
,
Dong Hyun Kim Department of Microbial Chemistry, College of Pharmacy, Kyung Hee University, Seoul, 130-701, South Korea
,
Ho Jin You Department of Pharmacology, College of Medicine, Chosun University, Gwangju, 501-759, South Korea
&
Jin Won Hyun Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju-si, 690-756, South KoreaCorrespondence[email protected]
 show all
Pages 720-729 | Received 06 Sep 2006, Published online: 07 Jul 2009
 
Sample our Behavioral Sciences journals, sign in here to start your access, latest two full volumes FREE to you for 14 days

Abstract

The present study investigated the cytoprotective properties of glycitein, a metabolite formed by the transformation of glycitin by intestinal microflora, against oxidative stress. Glycitein was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thereby preventing lipid peroxidation and DNA damage. Glycitein inhibited apoptosis of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2) via radical scavenging activity. Glycitein abrogated the activation of c-Jun N-terminal kinase (JNK) induced by H2O2 treatment and inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of JNK. Taken together, these findings suggest that glycitein protected H2O2 induced cell death in V79-4 cells by inhibiting ROS generation and JNK activation.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 940.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.