Emerging approaches for the detection of trimethylamine N-oxide: A gut derived metabolite

Abstract

Trimethylamine N-oxide (TMAO) is a gut-derived compound that has been linked to the development of cardiovascular disease and other health conditions. The detection of TMAO in biological samples is important for identifying individuals at risk for these conditions and for monitoring the effectiveness of interventions. In this article, we review several methods for the detection of TMAO, including LC-MS, Fluorescent assay, NMR, Sensors, etc. We also discuss the sensitivity, LOD, precision, and LOQ of each method and the toxicity, and pathogenesis of the metabolite.

Graphical Abstract

Keywords:

• Trimethylamine N-oxide
• TMAO
• TMA
• detection methods
• sensors
• gut metabolite

Disclosure statement

The authors report that there are no competing interests to declare.