Inhalation exposure to 1,2-dichloropropane: Distribution of blood and tissue concentrations of 1,2-dichloropropane in rats during and after exposure

Abstract

The present investigation was undertaken to determine the distribution and accumulation of 1,2-dichloropropane (DCP) in the blood, lung, liver, kidney, and abdominal fat of rats during and after inhalation exposure. Male rats were exposed to 80 or 500 ppm (v/v) DCP vapor for 360 min and the concentrations of DCP in the blood and tissues during the inhalation exposure period and after the end of the exposure period were measured. DCP accumulation in the abdominal fat was much greater than that in the blood and other tissues. Eighteen hours after the end of inhalation exposure, DCP could still be detected in the abdominal fat in the 80-ppm group, and in the blood, liver, kidney, and abdominal fat in the 500-ppm group. Our results are valuable data pertaining to the pharmacokinetics of DCP and to human health risk assessment of exposure to DCP vapor by inhalation.

Keywords:

• 1,2-Dichloropropane
• blood concentration
• tissue concentrations
• inhalation exposure

Acknowledgment

We wish to express our thanks to Professor David B. Alexander, Graduate School of Medical Sciences, Nagoya City University and Ms. Yuko Minoshima, Japan Bioassay Research Center, Japan Industrial Safety and Health Association, for proofreading this manuscript. We are also grateful to Mr. Masahiro Yamamoto, Mr. Shigeyuki Hirai, and Ms. Akiko Noda, Japan Bioassay Research Center, Japan Industrial Safety and Health Association, for technical support of this study.

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