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Journal of Environmental Science and Health, Part A
Toxic/Hazardous Substances and Environmental Engineering
Volume 49, 2014 - Issue 12
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ARTICLES

Inhalation exposure to 1,2-dichloropropane: Distribution of blood and tissue concentrations of 1,2-dichloropropane in rats during and after exposure

Makoto TakeJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, JapanCorrespondence[email protected]
,
Michiharu MatsumotoJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
,
Tetsuya TakeuchiJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
,
Mitsuru HaresakuJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
,
Hitomi KondoJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
,
Hideki SenohJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
,
Yumi UmedaJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
,
Takeji Takamura-EnyaDepartment of Applied Chemistry, Faculty of Engineering, Kanagawa Institute of Technology, Atsugi, Kanagawa, Japan
&
Shoji FukushimaJapan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
 show all
Pages 1341-1348 | Received 04 Feb 2014, Published online: 29 Jul 2014

References

  • Agency for Toxic Substances and Disease Registry (ATSDR). 1,2-Dichloropropane. Author: Atlanta, GA, 1999. Available at www.atsdr.cdc.gov/toxprofiles/tp134-C2.pdf (accessed Jan 2014).
  • Ministry of the Environment Government of Japan. Pollutant Release and Transfer Register. Environmental Health and Safety Division, Environmental Health Department, Ministry of the Environment Government of Japan: Tokyo, 2011. Available at www.env.go.jp/en/chemi/prtr/substances/index.html (accessed Jan 2014).
  • International Agency for Research on Cancer (IARC). Some halogenated hydrocarbons and pesticide exposures. IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 1986, 41, 131–147.
  • IARC. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide (Part three). IARC Monogr. Eval. Carcinog. Risks Hum. 1999, 71, 1393–1400.
  • Kumagai, S.; Kurumatani, N.; Arimoto, A.; Ichihara, G. Cholangiocarcinoma among offset colour proof-printing workers exposed to 1,2-dichloropropane and/or dichloromethane. Occup. Environ. Med. 2013, 70 (7), 508–510.
  • National Toxicology Program (NTP). Toxicology and carcinogenesis studies of 1,2-dichloropropane (propylene dichloride) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 263. Author: Bethesda, MD, 1986.
  • Matsumoto, M.; Umeda, Y.; Take, M.; Nishizawa, T.; Fukushima, S. Subchronic toxicity and carcinogenicity studies of 1,2-dichloropropane inhalation to mice. Inhal. Toxicol. 2013, 25(8), 435–443.
  • Umeda, Y.; Matsumoto, M.; Aiso, S.; Nishizawa, T.; Nagano, K.; Arito, H.; Fukushima, S. Inhalation carcinogenicity and toxicity of 1,2-dichloropropane in rats. Inha. Toxicol. 2010, 22(13), 1116–1126.
  • Timchalk, C.; Dryzga, M.D.; Smith, F.A.; Bartels, M.J. Disposition and metabolism of [14C]1,2-dichloropropane following oral and inhalation exposure in Fischer 344 rats. Toxicology 1991, 68(3), 291–306.
  • Take, M.; Ohnishi, M.; Nagano, K.; Yamamoto, S.; Fukushima, S. Design and performance of a system for blood collection of rats under whole-body inhalation exposure. J. Toxicol. Sci. 2009, 34(2), 221–226.
  • Take, M.; Takanobu, K.; Takeuchi, T.; Haresaku, M.; Matsumoto, M.; Nagano, K.; Yamamoto, S.; Fukushima, S. Distribution of blood and tissue concentrations in rats by inhalation exposure to 1,2-dichloroethane. J. Environ. Sci. Health Pt. A 2013, 48(9), 1031–1036.
  • Take, M.; Yamamoto, S.; Ohnishi, M.; Matsumoto, M.; Nagano, K.; Hirota, T.; Fukushima, S. Chloroform distribution and accumulation by combined inhalation plus oral exposure routes in rats. J. Environ. Sci. Health Pt. A 2010, 45(12), 1616–1624.
  • Take, M.; Ohnishi, M.; Yamamoto, S.; Matsumoto, M.; Nagano, K.; Fukushima, S. Distribution of 1,4-dioxane by combined inhalation plus oral exposure routes in rats. Intern. J. Environ. Anal. Chem. 2012, 92(15), 1715–1728.
  • Rozman, K.K.; Klaassen, C.D. Absorption, distribution, and excretion of toxicants. In Casarett & Doull's Toxicology, 6th Ed.; McGraw-Hill Companies, Inc.: New York, 2001; 91–111.
  • Rodriguez, C.E.; Mahle, D.A.; Gearhart, J.M.; Mattie, D.R.; Lipscomb, J.C.; Cook, R.S.; Barton, H.A. Predicting age-appropriate pharmacokinetics of six volatile organic compounds in the rat utilizing physiologically based pharmacokinetic modeling. Toxicol. Sci. 2007, 98(1), 43–56.
  • Gargas, M.L.; Burgess, R.J.; Voisard, D.E.; Cason, G.H.; Andersen, M.E. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 1989, 98(1), 87–99.
  • Hutson, D.H.; Moss, J.A.; Pickering, B.A. The excretion and retention of components of the soil fumigant D-D and their metabolites in the rat. Fd. Cosmet. Toxicol. 1971, 9(5), 677–680.
  • Jones, A.R.; Gibson, J. 1,2-Dichloropropane: metabolism and fate in the rat. Xenobiotica 1980, 10(11), 835–846.
  • Bartels, M.J.; Timchalk, C. 1,2-Dichloropropane: investigation of the mechanism of mercapturic acid formation in the rat. Xenobiotica 1990, 20(10), 1035–1042.

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