The patent review of the biological activity of tropane containing compounds

ABSTRACT

Introduction

Tropane-derived medications have historically played a substantial role in pharmacotherapy. Both natural and synthetic derivatives of tropane find application in addressing diverse medical conditions. Prominent examples of tropane-based drugs include hyoscine butylbromide, recognized for its antispasmodic properties, atropine, employed as a mydriatic, maraviroc, known for its antiviral effects. trospium chloride, utilized as a spasmolytic for overactive bladder, and ipratropium, a bronchodilator.

Areas covered

We compiled patents pertaining to the biological activity of substances containing tropane up to the year 2023 and categorized them according to the specific type of biological activity they exhibit. ScienceFinder, ScienceDirect, and Patent Guru were used to search for scientific articles and patent literature up to 2023.

Expert opinion

Pharmaceutical researchers in academic and industrial settings have shown considerable interest in tropane derivatives. Despite this, there remains a substantial amount of work to be undertaken. A focused approach is warranted for the exploration and advancement of both natural and synthetic bioactive molecules containing tropane, facilitated through collaborative efforts between academia and industry. Leveraging contemporary techniques and technologies in medicinal and synthetic chemistry, including high throughput screening, drug repurposing,and biotechnological engineering, holds the potential to unveil novel possibilities and accelerate the drug discovery process for innovative tropane-based pharmaceuticals.

KEYWORDS:

• Tropane
• modulators of neurotransmitter receptors
• antiviral
• antibacterial
• anticancer
• anti-inflammatory agents

Article highlights

• Tropane-derived medications have historically played a substantial role in pharmacotherapy.

• We compiled patents pertaining to the biological activity of substances containing tropane up to the year 2023.

• Commercially-used tropane drugs are reported.

• Biological significance of tropane derivatives as acetylcholine, serotonin and histamine receptors modulators, antiviral, antibacterial, anticancer,antiinflammatory, and antidiabetic agents, is discussed.

• The structure-activity relationships (SAR) of some pharmacological activities are also reported.

• Fourty six patents are cited among totally 123 references collected.

Declaration of interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Authors contribution statement

All authors contributed to collect the scientific material, writing the review article, and reviewing it.

Acknowledgments

The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code: (22UQU4350477DSR03).

Additional information

Funding

This paper was funded by the Deanship of Scientific Research at Umm Al-Qura University by Grant Code: (22UQU4350477DSR03).