Sleep disturbance, negative affect and health-related quality of life in patients with maintenance hemodialysis

ABSTRACT

The study was designed to examine the relationships between sleep disturbance, negative affect and quality of life among patients with maintenance hemodialysis. A total of 118 patients in Shanghai, China, with maintenance hemodialysis (>40 years old) participated in the study. They completed three questionnaires: the Positive and Negative Affect Scale (PANAS), the Pittsburgh Sleep Quality Index (PSQI) and the European Quality of 5-Dimensions (EQ-5D-5L). Results showed that male participants’ negative affect scored significantly higher than female participants’.The mean global PSQI score was 8.64 (poor sleepers score 6 or more); sleep disturbance affected 63.6% of the patients, which indicated that in general the participants’ sleep quality was relatively poor.The patients with worse sleep quality and negative affect were more likely to have a lower quality of life. In addition, the effect of the sleep disturbance on quality of life was mediated by negative affect (The Z value of Sobel test was -3.18, p< .01).These findings suggest sleep disturbance and negative affect were common among patients with maintenance hemodialysis and had a negative impact on their quality of life; negative affect may mediate the relationship between sleep disturbance and quality of life.

KEYWORDS:

• Sleep disturbance
• negative affect
• quality of life
• maintenance hemodialysis

Acknowledgments

Foundation: Shanghai Municipal Health Bureau Foundation，201740116; The Fourth Round of Three-year Action Plan on Public Health Discipline and Talent Program: Systemic Redesign and Demonstration for Early Detection, Evaluation and Management of Chronic Kidney Disease in Shanghai(SCREENING Study GWIV-18)

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the The Fourth Round of Three-year Action Plan on Public Health Discipline and Talent Program: Systemic Redesign and Demonstration for Early Detection, Evaluation and Management of Chronic Kidney Disease in Shanghai [SCREENING Study GWIV-18];Shanghai Municipal Health Bureau Foundation [201740116]