Vulvovaginal graft-versus-host disease: a review

Abstract

Hematopoietic cell transplantation (HCT) is associated with well-described gynecologic sequelae, including vulvovaginal graft-versus-host disease (GVHD). Vulvovaginal GVHD is a common complication of allogeneic HCT, but has been under-reported in the literature. Guidelines have been published only recently to recommend common terminology, treatment, and surveillance. This review summarizes the presentation, management, and surveillance aspects of vulvovaginal GVHD. We recommend a standardized referral between women undergoing HCT and an experienced gynecologist capable of managing this disease and treating sexual side effects.

摘要

造血细胞移植（HCT）与众所周知的妇科后遗症相关, 包括外阴阴道移植物抗宿主病（GVHD）。外阴阴道移植物抗宿主病是同种异体造血细胞移植的常见并发症, 但文献中报道不多。指南仅在最近才发布, 以推荐常用术语, 治疗和管理。这篇综述总结了外阴阴道移植物抗宿主病的临床表现, 治疗和监测方面内容。 我们建议接受HCT的女性标准化地转诊至有能力治疗这种疾病并治疗性相关副作用的经验丰富的妇科医生。

Keywords:

• Stem cell transplant
• graft-versus-host disease
• vulvovaginal graft-versus-host disease
• premature ovarian insufficiency

Potential conflict of interest

Dr Wolfman has been on an advisory board for Pfizer and has received an unrestricted grant from Pfizer. Dr Jacobson, Dr Wong, and Dr Li have no conflicts of interest.

Source of funding

Nil.