Prevalence of mild cognitive impairment in surgical menopause: subtypes and associated factors

Abstract

Objective

The aim of this study was to determine the prevalence and associated factors of mild cognitive impairment (MCI) and subtypes, amnestic MCI (aMCI) and non-amnestic MCI (naMCI), in women with surgical menopause.

Methods

We obtained the database containing information for 200 women with surgical menopause from our previous study. The Montreal Cognitive Assessment – total score, the Montreal Cognitive Assessment – memory index score (MoCA-MIS) and their age, years since menopause, education, medical and surgical history, hormone therapy use, exercise, sleep duration, alcohol use, smoking and family history of dementia were obtained. All participants without the MoCA-MIS were excluded.

Result

The average age of the 164 participants was 56.3 ± 6.9 years. The prevalence of MCI, aMCI and naMCI was 43.3%, 9.8% and 33.5%, respectively. The duration of education reduced MCI for 93% (95% confidence interval 0.03–0.20) of the women. In late postmenopause, hormone therapy >10 years showed 47% lower prevalence of MCI (age-adjusted odds ratio = 0.53, 95% confidence interval 0.22–1.28). Finally, length of education was the only independent factor associated with MCI and its subtypes.

Conclusion

We found a high prevalence of MCI and the non-amnestic subtype in women with surgical menopause. Further study is needed to clarify the long-term effects of surgical menopause on cognitive function.

Chinese abstract

目的：探讨手术绝经妇女轻度认知功能障碍(MCI)及其亚型遗忘性MCI(AMCI)和非遗忘性MCI(naMCI)的患病率及其相关因素。

方法：我们从既往的研究中获取了200名手术绝经妇女的信息的数据库。获得蒙特利尔认知评估-总分、蒙特利尔认知评估-记忆指数得分(MoCA-MIS)及其年龄、绝经年限、文化程度、内外科病史、激素应用、锻炼、睡眠时间、饮酒、吸烟和痴呆家族史。排除所有无MOCA-MIS的受试者。

结果：164名受试者的平均年龄为56.3±6.9岁。MCI、aMCI和naMCI患病率分别为43.3%、9.8%和33.5%。受教育年限使女性MCI降低了93%(95%CI 0.03-0.20)。在绝经后晚期, 激素治疗>10年显示MCI患病率降低47%(年龄调整的OR=0.53, 95%CI为0.22-1.28)。最后, 教育年限是MCI及其亚型唯一的独立影响因素。

结论：我们发现在手术绝经妇女中MCI和非遗忘亚型的患病率很高。手术绝经对认知功能的长期影响还需要进一步研究。

Keywords:

• Surgical menopause
• hormone therapy
• cognitive impairment
• amnestic
• mild cognitive impairment
• The Montreal Cognitive Assessment

Potential conflict of interest

The authors declare that they have no conflict of interests or financial relationships relevant to this article.

Additional information

Funding

This research was supported by the Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University [RA 57/005].