Hormone therapy effect on menopausal systemic lupus erythematosus patients: a systematic review

Abstract

Systemic lupus erythematosus (SLE) primarily affects women, who may need hormone therapy (HT) in menopause. There is, however, some concern as to its efficacy and safety. This systematic review aimed to determine the effect of HT on the activity of SLE and its safety. The study was a qualitative systematic review. Research was conducted with data retrieved from Embase, MEDLINE and Cochrane databases using MESH terms up to April 2021, with no bar on date or language. Sixteen studies were selected for analysis. Most of them showed HT to be effective in the treatment of menopausal symptoms with no impact in SLE activity, but one randomized clinical trial showed an increase in the number of thrombotic events. The present systematic review demonstrated the efficacy of HT for treating the menopausal symptoms of SLE patients. The risk of flare and thrombosis seems to be very low.

摘要

系统性红斑狼疮(SLE)主要影响需要激素治疗（HT）的绝经期女性。然而, 人们对其有效性和安全性有担忧。本系统综述旨在确定HT对SLE活动的影响及其安全性。该研究是一个定性的系统回顾。研究纳入了截止至2021年4月的从Embase、MEDLINE和Cochrane数据库检索到的数据, 应用MESH方法, 没有日期和语言的限制。最终选择16项研究进行分析。大多数研究表明HT治疗绝经期症状有效, 对SLE活动无影响, 但一项随机临床试验显示血栓事件增加。本系统综述证实了HT治疗SLE患者绝经期症状的疗效。SLE活动和血栓形成的风险似乎很低。

Keywords:

• Systemic lupus erythematosus
• hormone therapy
• menopause
• hormone replacement therapy

Potential conflict of interest

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by grants from Fundação de Amparo à Pesquisa do Estado de Sao Paulo [FAPESP 2015/03756-4] (to C.A.S. and E.B.); [FAPESP 2018/24224-9] (to J.M.S.Jr and E.C.B.]; Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq 304984/2020-5] (to C.A.S.); [#305242/2019-9] (to E.B.); [#301725/2017-9] (to J.M.S.Jr); Núcleo de Apoio à Pesquisa “Saúde da Criança e do Adolescente” da USP (NAP-CriAd) (to C.A.S.).