Plasma homocysteine levels and handgrip strength in postmenopausal women

Abstract

Objective

This study evaluated handgrip strength (HGS), circulating homocysteine levels and related factors in postmenopausal women.

Methods

This study is a sub-analysis of a prospective cohort of 303 postmenopausal women aged 62.7 ± 6.9 years who had HGS measures with a digital dynamometer as the primary outcome, and plasma homocysteine and creatinine levels and glomerular filtration rate (GFR) measures as the secondary outcomes.

Results

The average HGS was 22.5 ± 4.0 kg, 29.4% of women had dynapenia (HGS < 20 kg), adiposity was 40.3 ± 5.4% and 9.57% of women had hyperhomocysteinemia (homocysteine >15 μmol/l). There were no differences between tertiles of homocysteine and HGS (p = 0.641). Plasma homocysteine levels were unrelated to HGS (r = −0.06) and correlated with age (r = 0.17), GFR (r = −0.28) and creatinine (r = 0.23). Hyperhomocysteinemia was not associated with HGS (odds ratio [OR] = 0.98 [95% confidence interval (CI): 0.89; 1.08]) or dynapenia (OR = 1.10 [95% CI: 0.45; 2.47]). The risk of presenting low HGS were not significantly associated with homocysteine (OR = −0.08 [95% CI: −0.21; 0.06]) and were associated with age (OR = −0.23 [95% CI: −0.29; −0.17]), adiposity (OR = −6.52 [95% CI: −9.53; −3.50]) and creatinine (OR = 6.22 [95% CI: 2.48; 9.97]).

Conclusions

HGS and dynapenia were unrelated to hyperhomocysteinemia. Age, GFR and creatinine were significantly associated with plasma homocysteine levels.

摘要

目的:研究绝经后妇女的握力(HGS)、循环同型半胱氨酸水平及相关因素。

方法:本研究对303名年龄为62.7±6.9岁的绝经后妇女的前瞻性队列的亚分析, 这些妇女以数字测功器测量HGS为主要结果, 血浆同型半胱氨酸和肌酐水平以及肾小球滤过率(GFR)测量为次要结果。

结果:平均HGS为22.5±4.0 kg, 29.4%的女性有睡眠障碍(HGS < 20 kg), 40.3±5.4%和9.57%的女性有高同型半胱氨酸血症(同型半胱氨酸>15μmol/l)。同型半胱氨酸与HGS之间无差异(ρ＝0.641)。血浆同型半胱氨酸水平与HGS (r＝－0.06)无关, 与年龄(r＝0.17)、GFR (r＝－0.28)和肌酐(r＝－0.23)相关。高同型半胱氨酸血症与HGS无关(比值比[OR]＝0.98[95%可信区间(CI): 0.89;1.08])或动力减退(OR＝＝1.10 [95% CI: 0.45;2.47])。发生低HGS的风险与同型半胱氨酸无显著相关(OR＝－0.08 [95% CI:－0.21;0.06]), 且与年龄相关(OR＝－0.23 [95% CI:－0.29;－0.17]), 肥胖(OR＝－6.52 [95% CI:－9.53;－3.50])和肌酐(OR＝6.22 [95% CI: 2.48;9.97])。

结论:HGS和睡眠障碍与高同型半胱氨酸血症无关。年龄、GFR和肌酐与血浆同型半胱氨酸水平显著相关。

Keywords:

• Body mass index
• creatinine
• glomerular filtration rate
• homocysteine
• handgrip strength
• hyperhomocysteinemia
• mean corpuscular volume

Acknowledgements

This study has been done under the auspices of the Professorship in Obstetrics and Gynecological Research of the Hospital Universitario Dexeus, of the Universidad Autónoma de Barcelona. There are no linked research data sets for this article. Data will be made available on reasonable request.

Potential conflict of interest

The authors report no conflicts of interest.

Source of funding

This research was not funded by any commercial or non-profit organization or public agency.