Abstract
Objective
Risk-reducing salpingo-oophorectomy (RRSO) is advised before 40–45 years of age for BRCA1/2 mutation carriers. This study describes the effect of RRSO on lipid determinants, hemoglobin A1c (HbA1c) and C-reactive protein (CRP).
Methods
A total of 142 women with increased risk of ovarian cancer were included, 92 premenopausal and 50 postmenopausal. Serum levels of low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and total cholesterol, triglycerides, HbA1c and CRP were determined at three points in time: before (T0) and 6 weeks (T1) and 7 months (T2) following RRSO. The Hot Flush Rating Scale was administered at the same time points.
Results
In premenopausal women, levels of HDL-cholesterol, the cholesterol ratio and HBA1c increased significantly over time, although still staying within the reference range. In this group, hot flushes increased over time (p < 0.001). In postmenopausal women, no significant changes were observed following RRSO. At T2, serum LDL-cholesterol, triglycerides, HbA1c and CRP were significantly lower in premenopausal women compared to postmenopausal women, whereas HDL was increased.
Conclusions
Seven months after RRSO, the lipid profile in premenopausal women had changed, although still staying within the reference range. For postmenopausal women, we did not observe any significant changes. Our results do not suggest a worsening of cardiovascular risk within 7 months of RRSO.
摘要
目的: BRCA1/2突变携带者建议在40 ∼ 45岁前行降低风险的输卵管卵巢切除术(RRSO)。本研究描述了RRSO对血脂影响因素、血红蛋白A1c(HbA1c)和C反应蛋白(CRP)的影响。
方法: 142例卵巢癌高危妇女, 绝经前92例, 绝经后50例。分别于RRSO前(T0)、RRSO后6周(T1)、7个月(T2)测定血清低密度脂蛋白(LDL)-胆固醇、高密度脂蛋白(HDL)-胆固醇及总胆固醇、甘油三酯、HbA1c和C反应蛋白(CRP)水平。在同一时间点进行潮热评定量表测定。
结果: 在绝经前妇女中, 高密度脂蛋白-胆固醇水平、胆固醇比率和HBA1c水平随着时间的推移显著增加, 但仍保持在参考范围内。在这组人中, 潮热随着时间的推移而增加(p < 0.001)。在绝经后的妇女中, RRSO后没有观察到明显的变化。T2时, 绝经前妇女血清低密度脂蛋白、甘油三酯、HBA1c和C反应蛋白显著低于绝经后妇女, 而高密度脂蛋白升高。
结论: RRSO后7个月, 绝经前妇女的血脂谱发生了变化, 但仍保持在参考范围内。对于绝经后的女性, 我们没有观察到任何显著的变化。我们的结果并不表明RRSO后7个月内心血管风险恶化。
Potential conflict of interest
The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article.
Source of funding
Nil.