Polycystic ovary syndrome: associations with cardiovascular disease

Abstract

Polycystic ovary syndrome (PCOS), characterized by abnormal menstrual periods, elevated androgen levels and polycystic ovary morphology on ultrasound, is the most common endocrine disorder among females. PCOS is associated with cardiovascular disease (CVD) risk factors including diabetes, obesity, metabolic syndrome, adverse pregnancy outcomes such as pre-eclampsia and psychosocial distress including depression. Previous evidence on the association between PCOS and CVD is inconclusive but the latest 2023 International Evidence-Based PCOS Guideline identifies PCOS as a risk factor for CVD. This review will discuss the relationship between PCOS and CVD along with current direction for CVD screening and prevention among individuals with PCOS.

摘要

多囊卵巢综合征（PCOS）是女性最常见的内分泌疾病, 特征表现为月经周期异常、雄激素水平升高和超声下多囊卵巢形态。PCOS与心血管疾病（CVD）危险因素有关, 包括糖尿病、肥胖、代谢综合征、不良妊娠结局（如先兆子痫）和心理社会痛苦（包括抑郁）。先前关于PCOS和CVD之间关系的证据尚不确定, 但最新的2023年国际循证PCOS指南将PCOS确定为CVD的危险因素。本文将讨论PCOS与CVD的关系, 以及PCOS患者CVD筛查和预防的最新方向。

Keywords:

• Polycystic ovary syndrome
• women’s health
• cardiovascular disease

Potential conflict of interest

No potential conflict of interest was reported by the authors.

Additional information

Funding

International PCOS Guideline development is funded by the Australian government through the National Health and Medical Research Council (NHMRC) Centre for Research Excellence in Women’s Health in Reproductive Life (CRE WHiRL) [#1171592]. C.T.T. is also supported by grant [#1171592]. H.T. is funded by an NHMRC fellowship [#2009326].