Diagnostic and prognostic value of long noncoding RNAs in sepsis: a systematic review and meta-analysis

ABSTRACT

Objective

To explore the potential of long noncoding RNA (lncRNA) as a diagnostic and prognostic biomarker for patients with sepsis.

Methods

Literature was obtained from seven databases. Relevant data were examined by combining sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic orders ratio (DOR), and the area under the curve (AUC) of the summary receiver operating characteristic (SROC) curve with their corresponding 95% confidence intervals (CI) using a bivariate model.

Results

Seventeen works of literature were included for meta-analysis. The meta-analysis determined that combined SEN was 0.76 (95% C.I.: 0.69–0.82), combined SPE was 0.84 (95% C.I.: 0.79–0.88), combined PLR was 4.81 (95% C.I.: 3.70–6.25), combined NLR was 0.28 (95% C.I.: 0.22–0.36), combined DOR was 17.02 (95% C.I.: 11.96–24.22), and AUC was 0.88 (95% C.I.: 0.84–0.90), however, for prognostic meta-analysis, combined SEN was 0.82 (95% C.I.: 0.73–0.86), combined SPE was 0.69 (95% C.I.: 0.54–0.81), combined PLR was 2.69 (95% C.I.: 1.82–3.97), combined NLR was 0.25 (95% C.I.: 0.10–0.35), combined DOR was 10.63 (95% C.I.: 7.13–15.87), and AUC was 0.84 (95% C.I.: 0.81–0.87).

Conclusion

LncRNA possesses a significant diagnostic and prognostic ability for sepsis.

KEYWORDS:

• Long noncoding RNA
• sepsis
• prognosis
• diagnosis
• meta-analysis

Acknowledgment

We would like to thank Bullet Edits Limited for the linguistic editing and proofreading of the manuscript.

Declaration of interest

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Reviewers disclosure

Peer reviewers on this manuscript have no relevant financial relationships or otherwise to disclose.

Data availability statement

All data generated or analyzed in this study are included in this published article.

Abbreviations

lncRNA, long noncoding RNA

SEN, sensitivity

SPE, specificity

PLR, positive likelihood ratio

NLR, negative likelihood ratio

DOR, diagnostic orders ratio

AUC, area under the curve

SROC, summary receiver operating characteristic

CI, confidence interval

ICU, intensive care units

CRP, C-reactive protein

PCT, procalcitonin

H-FABP, Heart-type fatty acid binding protein

CNKI, China National Knowledge Infrastructure

QUADAS-2, Quality Assessment Tool for Diagnostic Accuracy Studies

COX2, cyclooxygenase 2

Supplementary material

Supplemental data for this article can be accessed online at https://doi.org/10.1080/14737159.2022.2125801

Additional information

Funding

This study was supported by the 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYGD18006).