Diagnostic and prognostic value of long noncoding RNAs in sepsis: a systematic review and meta-analysis

References

• Cecconi M, Evans L, Levy M, et al. Sepsis and septic shock. Lancet. 2018;392:75–87.
   PubMed Web of Science ®Google Scholar
• Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study. Lancet. 2020;395:200–211.
   PubMed Web of Science ®Google Scholar
• Xie J, Wang H, Kang Y, et al. The epidemiology of Sepsis in Chinese ICUs: a national cross-sectional survey. Crit Care Med. 2020;48:e209–e218.
   PubMed Web of Science ®Google Scholar
• Standage SW, Wong HR. Biomarkers for pediatric sepsis and septic shock. Expert Rev Anti Infect Ther. 2011;9:71–79.
   PubMed Web of Science ®Google Scholar
• Wacker C, Prkno A, Brunkhorst FM, et al. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis. 2013;13:426–435.
   PubMed Web of Science ®Google Scholar
• He S, Leng W, Du X, et al. Diagnostic significance of heart-type fatty acid-binding protein as a potential biomarker to predict the mortality rate of patients with sepsis: a systematic review and meta-analysis. Expert Rev Mol Diagn. 2022;22:379–386.
   PubMed Web of Science ®Google Scholar
• Paoli CJ, Reynolds MA, Sinha M, et al. Epidemiology and costs of sepsis in the United States-an analysis based on timing of diagnosis and severity level. Crit Care Med. 2018;46:1889–1897.
   PubMed Web of Science ®Google Scholar
• Wapinski O, Chang HY. Long noncoding RNAs and human disease. Trends Cell Biol. 2011;21:354–361.
   PubMed Web of Science ®Google Scholar
• Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 2016;73:2491–2509.
   PubMed Web of Science ®Google Scholar
• Wu H, Liu J, Li W, et al. LncRNA-HOTAIR promotes TNF-α production in cardiomyocytes of LPS-induced sepsis mice by activating NF-κB pathway. Biochem Biophys Res Commun. 2016;471:240–246.
   PubMed Web of Science ®Google Scholar
• Lu F, Hong Y, Liu L, et al. Long noncoding RNAs: a potential target in sepsis-induced cellular disorder. Exp Cell Res. 2021;406:112756.
   PubMed Web of Science ®Google Scholar
• Wang C, Liang G, Shen J, et al. Long non-coding RNAs as biomarkers and therapeutic targets in sepsis. Front Immunol. 2021;12:722004.
   PubMed Web of Science ®Google Scholar
• Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155:529–536.
   PubMed Web of Science ®Google Scholar
• Zamora J, Abraira V, Muriel A, et al. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol. 2006;6:31.
   PubMedGoogle Scholar
• Habibzadeh F, Habibzadeh P. The likelihood ratio and its graphical representation. Biochem Med (Zagreb). 2019;29:020101.
   PubMed Web of Science ®Google Scholar
• Reitsma JB, Glas AS, Rutjes AW, et al. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol. 2005;58:982–990.
   PubMed Web of Science ®Google Scholar
• Chu H, Cole SR. Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach. J Clin Epidemiol. 2006;59:1331–1332. author reply 1332-1333.
   PubMed Web of Science ®Google Scholar
• Harbord RM, Whiting P, Sterne JA, et al. An empirical comparison of methods for meta-analysis of diagnostic accuracy showed hierarchical models are necessary. J Clin Epidemiol. 2008;61:1095–1103.
   PubMed Web of Science ®Google Scholar
• Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560.
   PubMed Web of Science ®Google Scholar
• Hoaglin DC. Misunderstandings about Q and ‘Cochran’s Q test’ in meta-analysis. Stat Med. 2016;35:485–495.
   PubMed Web of Science ®Google Scholar
• Hellmich M, Lehmacher W. A ruler for interpreting diagnostic test results. Methods Inf Med. 2005;44:124–126.
   PubMed Web of Science ®Google Scholar
• Deeks JJ, Macaskill P, Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol. 2005;58:882–893.
   PubMed Web of Science ®Google Scholar
• He Y, Chen J, Zhou L, et al. The value of plasma long non-coding RNA MALAT1 in the diagnosis, severity and prognosis of sepsis. J. Nanjing Med. Univ(Nat Sci). 2021;41(12):1811–1815.
   Google Scholar
• Wu B, Liang W, Wang M. Expression and clinical significance of serum lncRNA IFNG⁃AS1 in sepsis patients. J Pra Med. 2020;36(5):590–592.
   Google Scholar
• Zhang W, Liu J, Zhang Q. Expression and clinical significance of LncRNA GASL1 in patients with sepsis. BMU J. 2021;44(2):108–115.
   Google Scholar
• Huang S, Qian K, Zhu Y, et al. Diagnostic value of the lncRNA NEAT1 in peripheral blood mononuclear cells of patients with sepsis. Dis Markers. 2017;2017:7962836.
   PubMed Web of Science ®Google Scholar
• Huang Q, Huang C, Luo Y, et al. Circulating lncRNA NEAT1 correlates with increased risk, elevated severity and unfavorable prognosis in sepsis patients. Am J Emerg Med. 2018;36:1659–1663.
   PubMed Web of Science ®Google Scholar
• Huang X, Zhao M. High expression of long non-coding RNA MALAT1 correlates with raised acute respiratory distress syndrome risk, disease severity, and increased mortality in sepstic patients. Int J Clin Exp Pathol. 2019;12:1877–1887.
   PubMed Web of Science ®Google Scholar
• Wang Y, Fu X, Yu B, et al. Long non-coding RNA THRIL predicts increased acute respiratory distress syndrome risk and positively correlates with disease severity, inflammation, and mortality in sepsis patients. J Clin Lab Anal. 2019;33:e22882.
   PubMed Web of Science ®Google Scholar
• Xu Y, Shao B. Circulating long noncoding RNA ZNFX1 antisense RNA negatively correlates with disease risk, severity, inflammatory markers, and predicts poor prognosis in sepsis patients. Medicine (Baltimore). 2019;98:e14558.
   PubMed Web of Science ®Google Scholar
• Zeng Q, Wu J, Yang S. Circulating lncRNA ITSN1-2 is upregulated, and its high expression correlates with increased disease severity, elevated inflammation, and poor survival in sepsis patients. J Clin Lab Anal. 2019;33:e22836.
   PubMed Web of Science ®Google Scholar
• Chen J, He Y, Zhou L, et al. Long non‑coding RNA MALAT1 serves as an independent predictive biomarker for the diagnosis, severity and prognosis of patients with sepsis. Mol Med Rep. 2020;21:1365–1373.
   PubMed Web of Science ®Google Scholar
• Liu W, Geng F, Yu L. Long non-coding RNA MALAT1/microRNA 125a axis presents excellent value in discriminating sepsis patients and exhibits positive association with general disease severity, organ injury, inflammation level, and mortality in sepsis patients. J Clin Lab Anal. 2020;34:e23222.
   PubMed Web of Science ®Google Scholar
• Liu B, Ren H, Chen J. LncRNA NEAT1 correlates with Th1 and Th17 and could serve as an assistant biomarker in sepsis. Biomark Med. 2021;15:1177–1186.
   PubMed Web of Science ®Google Scholar
• Liu Y, Peng H, Gui F. Long noncoding plasmacytoma variant translocation 1 facilitates the surveillance of acute respiratory distress syndrome and mortality prediction in sepsis. Biomark Med. 2021;15:401–412.
   PubMed Web of Science ®Google Scholar
• Wang H, Feng Q, Wu Y, et al. Association of circulating long non-coding RNA HULC expression with disease risk, inflammatory cytokines, biochemical index levels, severity-assessed scores, and mortality of sepsis. J Clin Lab Anal. 2021;35:e23656.
   PubMed Web of Science ®Google Scholar
• Yu B, Cui R, Lan Y, et al. Long non-coding RNA H19 as a diagnostic marker in peripheral blood of patients with sepsis. Am J Transl Res. 2021;13:2923–2930.
   PubMed Web of Science ®Google Scholar
• Chen J, Ren H, Liu B. Evaluating the potency of blood long noncoding RNA PVT1 as candidate biomarker reflecting inflammation, multiple organ dysfunction, and mortality risk in sepsis patients. J Clin Lab Anal. 2022;36:e24268.
   PubMed Web of Science ®Google Scholar
• Wang R, Zhao J, Wei Q, et al. Potential of circulating lncRNA CASC2 as a biomarker in reflecting the inflammatory cytokines, multi-organ dysfunction, disease severity, and mortality in sepsis patients. J Clin Lab Anal. 2022;36:e24569.
   PubMed Web of Science ®Google Scholar
• Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. Northbrook. 1992;101:1644–1655.
   Google Scholar
• Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39:165–228.
   PubMed Web of Science ®Google Scholar
• Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–810.
   PubMed Web of Science ®Google Scholar
• Cesana M, Cacchiarelli D, Legnini I, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 2011;147:358–369.
   PubMed Web of Science ®Google Scholar
• Maenner S, Müller M, Becker PB. Roles of long, non-coding RNA in chromosome-wide transcription regulation: lessons from two dosage compensation systems. Biochimie. 2012;94:1490–1498.
   PubMed Web of Science ®Google Scholar
• Wang K, Long B, Zhou LY, et al. CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation. Nat Commun. 2014;5:3596.
   PubMed Web of Science ®Google Scholar
• Carpenter S, Aiello D, Atianand MK, et al. A long noncoding RNA mediates both activation and repression of immune response genes. Science. 2013;341:789–792.
   PubMed Web of Science ®Google Scholar
• Lehnardt S. Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia. 2010;58:253–263.
   PubMed Web of Science ®Google Scholar
• Ji P, Diederichs S, Wang W, et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene. 2003;22:8031–8041.
   PubMed Web of Science ®Google Scholar
• Zhuang YT, Xu DY, Wang GY, et al. IL-6 induced lncRNA MALAT1 enhances TNF-α expression in LPS-induced septic cardiomyocytes via activation of SAA3. Eur Rev Med Pharmacol Sci. 2017;21:302–309.
   PubMed Web of Science ®Google Scholar
• Ding Y, Guo F, Zhu T, et al. Mechanism of long non-coding RNA MALAT1 in lipopolysaccharide-induced acute kidney injury is mediated by the miR-146a/NF-κB signaling pathway. Int J Mol Med. 2018;41:446–454.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang Y, Li Q, et al. Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury. Cent Eur J Immunol. 2022;47:8–19.
   PubMed Web of Science ®Google Scholar
• Zhang CC, Niu F. LncRNA NEAT1 promotes inflammatory response in sepsis-induced liver injury via the Let-7a/TLR4 axis. Int Immunopharmacol. 2019;75:105731.
   PubMed Web of Science ®Google Scholar