Chemical constituents of Antrodia camphorata submerged whole broth

Abstract

One new compound, 10-hydroxy-γ-dodecalactone (1) and three natural new compounds, 11-hydroxy-γ-dodecalactone (2), 2-(2-hydroxyethyl)phenol (3) and 12-hydroxydodecanoic acid methyl ester (4), together with eight known compounds, ergostatrien-3β-ol, ergosterol peroxide, methyl (4-hydroxyphenyl)acetate, vanillin, 4-hydroxybenzaldehyde, hexadecanoic acid, 5-methoxymethylfuran-2-carbaldehyde and 5-hydroxymethylfuran-2-carbaldehyde, all were isolated from the submerged whole broth of Antrodia camphorata. The structures of 1 and 2 were principally elucidated by spectral evidence and the absolute configuration was elucidated by the modified Mosher's method.

Keywords:

• Antrodia camphorata
• Submerged
• 10-hydroxy-γ-dodecalactone
• 11-hydroxy-γ-dodecalactone
• 2-(2-hydroxyethyl)phenol
• 12-hydroxydodecanoic acid methyl ester

Acknowledgement

This research was supported by the National Science Council of the Republic of China (NSC 91-2622-E-158-001-CC3).