Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 10
Submit an article Journal homepage
287
Views
4
CrossRef citations to date
0
Altmetric
Short Communications

The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells

Chia-Wei PhanFaculty of Medicine, Department of Anatomy, University of Malaya, Kuala Lumpur, Malaysia;Faculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, MalaysiaORCID Iconhttp://orcid.org/0000-0003-1373-1374
ORCID Icon,
Vikineswary SabaratnamFaculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia;Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, MalaysiaCorrespondence[email protected]
,
Wai-Kuan YongFaculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia
&
Sri Nurestri Abd MalekFaculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia;Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia
Pages 1229-1233 | Received 06 Jan 2017, Accepted 02 May 2017, Published online: 25 May 2017
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

Chalcones are a group of compounds widely distributed in plant kingdom. The aim of this study was to assess the neurite outgrowth stimulatory activity of selected chalcones, namely helichrysetin, xanthohumol and flavokawin-C. Using adherent rat pheochromocytoma (PC12 Adh) cells, the chalcones were subjected to neurite outgrowth assay and the extracellular nerve growth factor (NGF) levels were determined. Xanthohumol (10 μg/mL) displayed the highest (p < 0.05) percentage of neurite-bearing PC12 Adh cells and the highest (p < 0.05) NGF level in the culture medium of xanthohumol-treated cells. While, helichrysetin induced a moderately high numbers of neurite-bearing cells, flavokawin-C did not stimulate neurite outgrowth. This work supports the potential use of xanthohumol as a potential neuroactive compound to stimulate neurite outgrowth.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 861.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.