Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 32, 2018 - Issue 10
Submit an article Journal homepage
287
Views
4
CrossRef citations to date
0
Altmetric
Short Communications

The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells

Chia-Wei PhanFaculty of Medicine, Department of Anatomy, University of Malaya, Kuala Lumpur, Malaysia;Faculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, MalaysiaORCID Iconhttp://orcid.org/0000-0003-1373-1374
ORCID Icon,
Vikineswary SabaratnamFaculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia;Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, MalaysiaCorrespondence[email protected]
,
Wai-Kuan YongFaculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia
&
Sri Nurestri Abd MalekFaculty of Science, Mushroom Research Centre, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia;Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur, Malaysia
Pages 1229-1233 | Received 06 Jan 2017, Accepted 02 May 2017, Published online: 25 May 2017

References

  • Jiwrajka M, Phillips A, Butler M, Rossi M, Pocock JM. 2016. The plant-derived chalcone 2,2′,5′-trihydroxychalcone provides neuroprotection against toll-like receptor 4 triggered inflammation in microglia. Oxid Med Cell Longev. Article number 6301712. doi:10.1155/2016/6301712.
  • Kaya-Tilki E, Dikmen M, Ozturk Y. 2016. Effects of DNMT and HDAC inhibitors (RG108 and Trichostatin A) on NGF-induced neurite outgrowth and cellular migration. Int J Pharmacol. 12:351–360.10.3923/ijp.2016.351.360
  • Li Y, Matsunaga K, Kato R, Ohizumi Y. 2001. Verbenachalcone, a novel dimeric dihydrochalcone with potentiating activity on nerve growth factor-action from Verbena littoralis. J Nat Prod. 64:806–808.10.1021/np000602w
  • Manni L, Rocco ML, Bianchi P, et al. 2013. Nerve growth factor: basic studies and possible therapeutic applications. Growth Factors. 31:115–122.10.3109/08977194.2013.804073
  • More SV, Koppula S, Kim IS, Kumar H, Kim BW, Choi DK. 2012. The role of bioactive compounds on the promotion of neurite outgrowth. Molecules. 17:6728–6753.10.3390/molecules17066728
  • Oberbauer E, Urmann C, Steffenhagen C, Bieler L, Brunner D, Furtner T, Humpel C, Bäumer B, Bandtlow C, Couillard-Despres S, et al. 2013. Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective. J Nutrit Biochem. 24:1953–1962.10.1016/j.jnutbio.2013.06.005
  • Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. 2015. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 35:355–368.
  • Phan CW, Lee GS, Hong SL, Wong YT, Brkljača R, Urban S, Abd Malek SN, Sabaratnam V. 2014. Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3 K-Akt signaling pathways. Food Funct. 5:3160–3169.10.1039/C4FO00452C
  • Phan CW, David P, Sabaratnam V. 2017. Edible and medicinal mushrooms: emerging brain food for the mitigation of neurodegenerative diseases. J Med Food. 20:1–10.10.1089/jmf.2016.3740
  • Qi J, Ojika M, Sakagami Y. 1999. Differentiation in a rat PC12 cell line induced by ostruthin and (-)-bornyl ferulate, constituents of a Chinese herbal medicine. Biosci Biotechnol Biochem. 63:1501–1502.10.1271/bbb.63.1501
  • Shigeta K, Ootaki K, Tatemoto H, Nakanishi T, Inada A, Muto N. 2002. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. Biosci Biotechnol Biochem. 66:2491–2494.10.1271/bbb.66.2491
  • Spoerri PE, Romanello S, Petrelli L, Negro A, Dal Toso R, Leon A, Skaper SD. 1992. Nerve growth factor (NGF) receptors in a central nervous system glial cell line: upregulation by NGF and brain-derived neurotrophic factor. J Neurosci Res. 33:82–90.10.1002/(ISSN)1097-4547
  • Tsang CK, Ina A, Goto T, Kamei Y. 2005. Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells. Neurosci. 132:633–643.10.1016/j.neuroscience.2005.01.028
  • Tuszynski MH, Thal L, Pay M, Salmon DP, U HS, Bakay R, Patel P, Blesch A, Vahlsing HL, Ho G, et al. 2005. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer’s disease. Nat Med. 11:551–555.10.1038/nm1239
  • Wang W, Dai R, Yan H, Han C, Liu L. 2015. Current situation of PC12 cell use in neuronal injury study. Int J Biotechnol Well Ind. 4:61–66.
  • Yeh LA, Padmanaban D, Ho P, Xing X, Rowley P, Morse LJ, Jensen RV, Cuny GD. 2005. Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression. Bioorg Med Chem Lett. 15:1193–1196.10.1016/j.bmcl.2004.12.001
  • Yin H, Hou X, Tao T, Lv X, Zhang L, Duan W. 2015. Neurite outgrowth resistance to rho kinase inhibitors in PC12 Adh cell. Cell Biol Int. 39:563–576.10.1002/cbin.v39.5
  • Zheng Y, Wang X, Gao S, Ma M, Ren G, Liu H, Chen X. 2015. Synthesis and antifungal activity of chalcone derivatives. Nat Prod Res. 29:1804–1810.10.1080/14786419.2015.1007973

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.