Two new dammarane-type saponins from radix and rhizomes of Panax ginseng C. A. Meyer

Abstract

Two new dammarane-type ginsenosides elucidated as 6-O-[α-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl]-dammar-24-ene-3β, 6α, 12β, 20S-tetraol, named 20(S)-Ginsenoside Re₁₀ (4); 6-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-[α-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl]-dammar-24-ene-3β, 6α, 12β, 20R-tetraol, named 20(R)-Ginsenoside Re₁₁ (8); along with one steroidal saponin (1) and six known triterpenoid ginsenosides (2, 3, 5, 6, 7 and 9) were isolated from the radix and rhizomes of mountain-cultivated ginseng (Panax ginseng C. A. Meyer, family Araliaceae). Their structures were determined by comprehensive chemical and spectroscopic analysis. In addition, what’s even more concerning is that protodioscin was isolated for the first time from Panax ginseng.

Graphical Abstract

Keywords:

• Panax ginseng
• 20(S)-Ginsenoside Re₁₀
• 20(R)-Ginsenoside Re₁₁
• Protodioscin

Disclosure statement

The authors declare no conflicts of interest.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (No. U20A20407) and Liaoning Revitalization Talents Program (XLYC1902119).