Heptaellipside A, a rare new 2,28-bidesmosidic lupane-type saponin from the leaves of Heptapleurum ellipticum

Abstract

For the first time, phytochemical constituents of the leaves of Heptapleurum ellipticum were investigated. One rare new 2,28-bidesmosidic lupane-type saponin, named heptaellipside A (1), along with four other lupane-type analogs (2–5) were purified by combining differently chromatographic methods. All of the separated compounds (1–5) were communicated for the first time from H. ellipticum. The structures of them were definitely illustrated following extensive and comprehensive UV/VIS, FTIR, HRMS/ESI, and NMR techniques. Further, all isolated compounds were evaluated for their α-glucosidase and α-amylase inhibition. As the results, compound 3 respectively exhibited stronger in both inhibitory activities against α-glucosidase and α-amylase (IC₅₀ values of 15.53 and 26.93 μM), than the acarbose standard (IC₅₀ values of 214.50 and 143.48 μM).

Graphical Abstract

Keywords:

• Araliaceae
• Heptapleurum ellipticum
• heptaellipside A
• 2,28-bidesmosidic saponin
• α-glucosidase inhibition
• α-amylase inhibition

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research is funded by the Ministry of Education and Training, Project B2023-TKG-03.