Article title: Methylene-tetrahydrofolate reductase gene C677Tand A1298C polymorphisms as a risk factor for Crimean-Congo hemorrhagic fever
Authors: Nevin Karakus, Fazilet Duygu, Aydin Rustemoglu, and Serbulent Yigit
Journal: Nucleosides, Nucleotides & Nucleic Acids
DOI: https://doi.org/10.1080/15257770.2022.2085296
The author of the article has made some changes in the text. The corrections are:
In the Abstract section the below text has been deleted
After dividing the CCHF patients into different groups, we found that AC and AC + CC genotype frequencies of A1298C polymorphism were higher in Non-fatal patients compared to controls (p = 0.014 and p = 0.027, respectively).
Genotypes consisting C allele of A1298C polymorphism poses a risk for CCHF in Non-fatal group and
In the result section the line
“In the C677T polymorphism, we have not been able to find a statistically significant difference in terms of genotype” has been changed to “In the C677T and A1298C polymorphisms, we have not been able to find a statistically significant difference in terms of genotype”
The text “However in terms of A1298C polymorphism, in the comparison of non-fatal vs. controls, we found that there are significant differences between non-fatal and controls in terms of genotype decencies (AC vs. AA p = 0.014, OR (95% Cl)= 1.8 (1.13-3.15) and AC + CC vs. AA p = 0.027, OR (95% Cl)= 1.7 (1.06-2.85))” has been deleted.
In the discussion section
“When we compared allele and genotype frequencies, we only found a difference in Non-fatal CCHF patients vs. controls comparison in terms of MTHFR gene A1298C polymorphism genotype decencies (p = 0.014 and p = 0.027). AC genotype frequency (55.1% vs. 39.4%) and AC + CC genotype frequency (60.4% vs. 47.0%) were higher in Non-fatal CCHF patients compared to controls.” has been deleted.
The line “We found no statistically significant differences in terms of other group encounters and C667T polymorphism” has been changed to “We found no statistically significant differences in terms of group encounters and C667T and A1298C polymorphisms.”
The table 6 has been changed.
In the conclusion section