There is no association between rs6296 and alcoholism: a meta-analysis

Abstract

Previous studies have reported controversial results about the association between rs6296 and alcoholism. Thus, a meta-analysis was performed to further explore this association. A comprehensive search was conducted to identify relevant case-control or cohort studies (up to December 1, 2017). A fixed- or random-effect model was selected as a pooling method depending on the heterogeneity among studies. The heterogeneity was measured by Q test and I² statistic. The Harbord and Peters test was used to estimate publication bias. Fifteen English articles with 16 outcomes and 5,429 participants were included in this meta-analysis. A fixed-effect model was chosen, and the pooled result showed that rs6296 was not related to alcoholism (z = 1.93, p = .053). The Harbord and Peters test showed that there was no publication bias. This meta-analysis indicated that rs6296 may be not be significantly associated with alcoholism, which needs to be further confirmed by future research.

Keywords:

• Rs6296
• receptor
• serotonin
• 5-HT1B
• alcoholism
• meta-analysis
• association

Disclosure statement

Xueli Zhang, Xuefeng Geng, Na Sun, Suyun Li, Jing Li, Suzhen Wang, and Qiang Wang declared that they have no conflict of interest.

Additional information

Funding

This study was sponsored by the National Natural Science Foundation of China under Grant Number 81473071 and the National Natural Science Foundation of China under Grant Number 81872719.