53
Views
2
CrossRef citations to date
0
Altmetric
Review

There is no association between rs6296 and alcoholism: a meta-analysis

, , , , , & show all

References

  • Barnes, N. M., & Sharp, T. (1999). A review of central 5-HT receptors and their function. Neuropharmacology, 38(8), 1083–1152. doi:10.1016/S0028-3908(99)00010-6
  • Cao, J.-X., Hu, J., Ye, X.-M., Xia, Y., Haile, C. A., Kosten, T. R., & Zhang, X. Y. (2011). Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. Brain Research, 1376, 1–9. doi:10.1016/j.brainres.2010.12.039
  • Cao, J., LaRocque, E., & Li, D. (2013). Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. [Meta-analysis research support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 169–176. doi:10.1002/ajmg.b.32128
  • Cigler, T., LaForge, K. S., McHugh, P. F., Kapadia, S. U., Leal, S. M., & Kreek, M. J. (2001). Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: No association with cocaine or alcohol abuse or dependence. American Journal of Medical Genetics, 105(6), 489–497. doi:10.1002/ajmg.1473
  • Contini, V., Bertuzzi, G. P., Polina, E. R., Hunemeier, T., Hendler, E. M., Hutz, M. H., & Bau, C. H. D. (2012). A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. [Research Support, Non-U.S. Gov't]. Drug and Alcohol Dependence, 122(1-2), 100–104. doi:10.1016/j.drugalcdep.2011.09.020
  • Crabbe, J. C., Phillips, T. J., Feller, D. J., Hen, R., Wenger, C. D., Lessov, C. N., & Schafer, G. L. (1996). Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. [Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.]. Nature Genetics, 14(1), 98–101. doi:10.1038/ng0996-98
  • Du, Y., Nie, Y., Li, Y., & Wan, Y. J. (2011). The association between the SLC6A3 VNTR 9-repeat allele and alcoholism-a meta-analysis. [Meta-Analysis Research Support, N.I.H., Extramural]. Alcohol Clin Exp Res, 35(9), 1625–1634. doi:10.1111/j.1530-0277.2011.01509.x
  • Duan, J., Sanders, A. R., Molen, J. E. V., Martinolich, L., Mowry, B. J., Levinson, D. F., … Gejman, P. V. (2003). Polymorphisms in the 5'-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Molecular Psychiatry, 8(11), 901–910. doi:10.1038/sj.mp.4001403
  • Edenberg, H. J. (2007). The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants. [Research Support, N.I.H., Extramural Review]. Alcohol Res Health, 30(1), 5–13.
  • Evangelou, E., Maraganore, D. M., & Ioannidis, J. P. (2007). Meta-analysis in genome-wide association datasets: Strategies and application in Parkinson disease. [Meta-Analysis Research Support, Non-U.S. Gov't]. PLoS One, 2(2), e196. doi:10.1371/journal.pone.0000196
  • Fehr, C., Grintschuk, N., Szegedi, A., Anghelescu, I., Klawe, C., Singer, P., … Dahmen, N. (2000). The HTR1B 861G > C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. Psychiatry Research, 97(1), 1–10. doi:10.1016/S0165-1781(00)00215-8
  • Feighner, J., Robins, E., Guze, S., Woodruff, R., Winokur, G., & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26(1), 57–63. doi:10.1001/archpsyc.1972.01750190059011
  • Ferraguti, G., Pascale, E., & Lucarelli, M. (2015). Alcohol addiction: A molecular biology perspective. [Review]. Current Medicinal Chemistry, 22(6), 670–684. doi:10.2174/0929867321666141229103158
  • Fish, E. W., McKenzie-Quirk, S. D., Bannai, M., & Miczek, K. A. (2008). 5-HT(1B) receptor inhibition of alcohol-heightened aggression in mice: Comparison to drinking and running. [Research Support, N.I.H., Extramural]. Psychopharmacology (Psychopharmacology), 197(1), 145–156. doi:10.1007/s00213-007-1017-3
  • Gorwood, P., Aissi, F., Batel, P., Adès, J., Cohen-Salmon, C., Hamon, M., … Lanfumey, L. (2002). Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: Of mice and men. [Research Support, Non-U.S. Gov't]. Brain Research Bulletin, 57(1), 103–107. doi:10.1016/s0361-9230(01)00641-4
  • Harbord, R. M., Egger, M., & Sterne, J. A. (2006). A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Statistics in Medicine, 25(20), 3443–3457. doi:10.1002/sim.2380
  • Hasegawa, Y., Higuchi, S., Matsushita, S., & Miyaoka, H. (2002). Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. [Comparative Study]. Journal of Neural Transmission, 109(4), 513–521. doi:10.1007/s007020200042
  • Hasin, D. (2003). Classification of alcohol use disorders. Alcohol Research & Health: The Journal of the National Institute on Alcohol Abuse and Alcoholism, 27(1), 5–17.
  • Higgins, J. P., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. [Research Support, Non-U.S.]. Statistics in Medicine, 21(11), 1539–1558. doi:10.1002/sim.1186
  • Higgins, J. P., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003). Measuring inconsistency in meta-analyses. [Research Support, Non-U.S.]. BMJ, 327(7414), 557–560. doi:10.1136/bmj.327.7414.557
  • Huang, Y. Y., Grailhe, R., Arango, V., Hen, R., & Mann, J. J. (1999). Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Neuropsychopharmacology, 21(2), 238–246. doi:10.1016/S0893-133X(99)00030-5
  • Huang, Y-y., Oquendo, M. A., Harkavy Friedman, J. M., Greenhill, L. L., Brodsky, B., Malone, K. M., … Mann, J. J. (2003). Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Neuropsychopharmacology, 28(1), 163–169. doi:10.1038/sj.npp.1300000
  • Iyer-Eimerbrink, P. A., & Nurnberger, J. I. Jr. (2014). Genetics of alcoholism. [Review]. Current Psychiatry Reports, 16(12), 518. doi:10.1007/s11920-014-0518-0
  • Kranzler, H. R., Gelernter, J., Anton, R. F., Arias, A. J., Herman, A., Zhao, H., … Covault, J. (2009). Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. [Clinical Trial Comparative Study Multicenter Study Research Support, N.I.H., Extramural]. Alcoholism: Clinical and Experimental Research, 33(5), 925–930. doi:10.1111/j.1530-0277.2009.00913.x
  • Kranzler, H. R., Hernandez-Avila, C. A., & Gelernter, J. (2002). Polymorphism of the 5-HT1B receptor gene (HTR1B) strong within-locus linkage disequilibrium without association to antisocial substance dependence. Neuropsychopharmacology, 26(1), 115–122. doi:10.1016/S0893-133X(01)00283-4
  • Kriem, B., Abraini, J. H., & Rostain, J. C. (1996). Role of 5-HT1b receptor in the pressure-induced behavioral and neurochemical disorders in rats. [Research Support, Non-U.S. Gov't]. Pharmacology Biochemistry and Behavior, 53(2), 257–264. doi:10.1016/0091-3057(95)00209-X
  • Lappalainen, J., Long, J. C., Eggert, M., Ozaki, N., Robin, R. W., Brown, G. L., … Goldman, D. (1998). Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. [Comparative Study Research Support, U.S. Gov't, P.H.S.]. Archives of General Psychiatry, 55(11), 989–994. doi:10.1001/archpsyc.55.11.989
  • Li, D., Zhao, H., & Gelernter, J. (2012). Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. [Meta-Analysis Research Support, N.I.H., Extramural]. Human Genetics, 131(5), 725–737. doi:10.1007/s00439-011-1116-4
  • McHugh, R. K., Hofmann, S. G., Asnaani, A., Sawyer, A. T., & Otto, M. W. (2010). The serotonin transporter gene and risk for alcohol dependence: A meta-analytic review. [Meta-Analysis Research Support, N.I.H., Extramural Review]. Drug and Alcohol Dependence, 108(1-2), 1–6. doi:10.1016/j.drugalcdep.2009.11.017
  • Muller, C. P., & Homberg, J. R. (2015). The role of serotonin in drug use and addiction. [Research Support, Non-U.S. Gov't Review]. Behavioural Brain Research, 277, 146–192. doi:10.1016/j.bbr.2014.04.007
  • NCBI. (2018). Reference SNP (refSNP) Cluster Report: Rs6296. Retrieved from https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=6296.
  • Panagiotou, O. A., Willer, C. J., Hirschhorn, J. N., & Ioannidis, J. P. (2013). The power of meta-analysis in genome-wide association studies. [Research Support, N.I.H., Extramural Review]. Annual Review of Genomics and Human Genetics, 14(1), 441–465. doi:10.1146/annurev-genom-091212-153520
  • Patsopoulos, N. A., Evangelou, E., & Ioannidis, J. P. (2008). Sensitivity of between-study heterogeneity in meta-analysis: Proposed metrics and empirical evaluation. [Research Support, Non-U.S. International Journal of Epidemiology, 37(5), 1148–1157. doi:10.1093/ije/dyn065
  • Phillips, T. J., Belknap, J. K., Buck, K. J., & Cunningham, C. L. (1998). Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption. [Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.]. Mamm Genome, 9(12), 936–941.
  • Prescott, C. A., & Kendler, K. S. (1999). Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. [Research Support, U.S. Gov't, P.H.S. Twin Study]. American Journal of Psychiatry, 156(1), 34–40. doi:10.1176/ajp.156.1.34
  • Sander, T., Ostapowicz, A., Samochowiec, J., Smolka, M., Rommelspacher, H., Winterer, G., & Schmidt, L. G. (2000). Evaluation of an allelic association of the serotonin 5-HT1B G681C polymorphism with antisocial alcoholism in the German population. Addiction Biology, 5(2), 167–172. doi:10.1080/13556210050003757
  • Sari, Y. (2004). Serotonin1B receptors: From protein to physiological function and behavior. [Review]. Neuroscience & Biobehavioral Reviews, 28(6), 565–582. doi:10.1016/j.neubiorev.2004.08.008
  • Sari, Y. (2013). Role of 5-hydroxytryptamine 1B (5-HT1B) receptors in the regulation of ethanol intake in rodents. [Research Support, N.I.H., Extramural Review]. Journal of Psychopharmacology, 27(1), 3–12. doi:10.1177/0269881112463126
  • Saudou, F., Amara, D., Dierich, A., LeMeur, M., Ramboz, S., Segu, L., … Hen, R. (1994). Enhanced aggressive behavior in mice lacking 5-HT1B receptor. [Comparative Study Research Support, Non-U.S. Gov't]. Science, 265(5180), 1875–1878. doi:10.1126/science.8091214
  • Sinha, R., Cloninger, C. R., & Parsian, A. (2003). Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism. [Research Support, U.S. Gov't, P.H.S.]. American Journal of Medical Genetics, 121B(1), 83–88. doi:10.1002/ajmg.b.20064
  • Sokoloff, P., Le Foll, B., Perachon, S., Bordet, R., Ridray, S., & Schwartz, J. C. (2001). The dopamine D3 receptor and drug addiction. Neurotoxicity Research, 3(5), 433–441.
  • Sterne, J. A., Gavaghan, D., & Egger, M. (2000). Publication and related bias in meta-analysis: Power of statistical tests and prevalence in the literature. Journal of Clinical Epidemiology, 53(11), 1119–1129.
  • Sun, H.-F. S., Chang, Y.-T., Fann, C. S.-J., Chang, C.-J., Chen, Y.-H., Hsu, Y.-P., … Cheng, A. T.-A. (2002). Association study of novel human serotonin 5-HT1B polymorphisms with alcohol dependence in Taiwanese Han. Biological Psychiatry, 51(11), 896–901. doi:10.1016/S0006-3223(01)01366-X
  • Tawa, E. A., Hall, S. D., & Lohoff, F. W. (2016). Overview of the genetics of alcohol use disorder. Alcohol and Alcoholism, 51(5), 507–514. doi:10.1093/alcalc/agw046
  • Tobias, A. (1999). Assessing the influence of a single study in the meta-analysis estimate. Stata Technical Bulletin, 8(41), 7526–7529.
  • Wang, J. C., Hinrichs, A. L., Stock, H., Budde, J., Allen, R., & Bertelsen, S. (2004). Evidence of common and specific genetic effects: Association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. [Comparative Study Research Support, U.S. Gov't, P.H.S.]. Human Molecular Genetics, 13(17), 1903–1911. doi:10.1093/hmg/ddh194
  • Wang, T.-Y., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Chen, S.-H., Chu, C.-H., … Lu, R.-B. (2012). Interaction between serotonin transporter and serotonin receptor 1 B genes polymorphisms may be associated with antisocial alcoholism. [Research Support, Non-U.S. Gov't]. Behavioral and Brain Functions, 8(1), 18. doi:10.1186/1744-9081-8-18
  • WHO. (2014). Global status report on alcohol and health, 2014. Vii.
  • Yan, Q. S., Zheng, S. Z., & Yan, S. E. (2004). Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: A study with dual-probe microdialysis. [Research Support, U.S. Gov't, Non-P.H.S.]. Brain Research, 1021(1), 82–91. doi:10.1016/j.brainres.2004.06.053
  • Yasseen, B., Kennedy, J. L., Zawertailo, L. A., & Busto, U. E. (2010). Comorbidity between bipolar disorder and alcohol use disorder: Association of dopamine and serotonin gene polymorphisms. [Research Support, Non-U.S. Gov't]. Psychiatry Res, 176(1), 30–33. doi:10.1016/j.psychres.2008.12.009

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.