Modification of fullerene with amino acids as a method for obtaining biocompatible materials with a protective effect

Abstract

Fullerenes and their derivatives have great potential for use as materials for medicine and biology. Fullerenes can enter into various reactions due to the presence of double bonds in their structure; it has also been repeatedly noted in the literature that the molecules have antiradical activity, biocompatibility, the ability to pass through biobarriers and immobilize various active molecules. In this work, a water-soluble adduct of C₆₀ fullerene with glycine was synthesized, its physicochemical properties, biocompatibility were studied, and a protective effects toward collagen photodegradation as well as in the model reaction of human serum albumin glycation was shown.

Keywords:

• Fullerene
• biocompatibility
• DNA
• collagen
• photodegradation
• glycation

Acknowledgements

The equipment of the following Resource Centres of the Research Park of Saint Petersburg State University was used: Computing Centre, the Centre for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics, Magnetic Resonance Research Centre, Centre for Chemical Analysis and Materials Research, Thermogravimetric and Calorimetric Research Centre.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availibility statement

The authors confirm that the data supporting the findings of this study are available within the article and its supplementary materials.

Additional information

Funding

The work was carried out with the financial support of the Ministry of Health of the Russian Federation ‘Development of a radioprotector based on water soluble forms of nanocarbon modified with L-amino acids’ EGISU: 123020800170-8.