RNA Degradation in Yeast and Human Mitochondria

Jan Piwowarski Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Andrzej Dziembowski Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Aleksandra Dmochowska Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Michal Minczuk Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Rafal Tomecki Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Kamil Gewartowski Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Piotr P. Stepien Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

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Abstract

RNA turnover in yeast mitochondria is controlled by the complex called degradosome, which consists of two nuclear-encoded proteins: the SUV3 gene codes for an RNA helicase and the DSS1 gene codes for an RNase. In contrast to yeast, much less is known about RNA degradation in human mitochondria. We suggest that the key enzyme involved in this process is nuclear-encoded polynucleotide phosphorylase, hPNPase.

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RNA Degradation in Yeast and Human Mitochondria

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