Correction

This article refers to:

Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort

Article title: Associations between placental CpG methylation of metastable epialleles and childhood body mass index across ages one, two and ten in the Extremely Low Gestational Age Newborns (ELGAN) cohort

Table 1. Demographic characteristics of the subset of the ELGAN cohort comprising the present study (n = 411)

	N (%) or mean (SD)
Infant Sex
Male	215 (52.3)
Female	196 (47.7)
BMI at age 1	16.7 (2.5)
Missing	32
BMI at age 2	16.0 (1.7)
Missing	34
BMI at age 10	17.7 (4.0)
Missing	7
Maternal BMI	25.4 (7.0)
Missing	13
Maternal Age	29.4 (6.7)
Gestational Age (Weeks)	26 (1.3)
Public Insurance
Yes	142 (34.9)
No	265 (65.1)
Missing	4
Maternal Race
White	252 (61.9)
Black	115 (28.3)
Other	40 (9.8)
Missing	4
Exposure to first- or secondhand smoking
Yes	93 (23.3)
No	307 (76.8)
Missing	11
Multiple Gestations
Yes	110 (26.8)
No	301 (73.2)
SD: standard deviation

Table 2. Placental CpG sites (n = 39) corresponding to metastable epialleles that are associated with BMI z-score across ages one, two, and ten globally

Probe ID	CHR	Gene	Position	β (95% CI)	p	q
cg00162191	1	HFM1	Body	-0.003 (-0.005, -0.001)	0.01	0.25
cg11097064	2	HDAC4	Body	0.003 (0.001, 0.005)	0.01	0.25
cg22068400	2			-0.003 (-0.006, 0)	0.04	0.30
cg25433157	2			-0.004 (-0.007, 0)	0.05	0.30
cg02447542	3			-0.001 (-0.002, 0)	0.01	0.25
cg18670801	4			-0.003 (-0.005, -0.001)	0.01	0.25
cg04492927	5	BTNL9	Body	-0.003 (-0.006, 0)	0.05	0.30
cg14886255	5	MGAT4B	Body	0.003 (0, 0.006)	0.02	0.28
cg24114444	5	NSA2;GFM2	TSS1500;5’UTR	-0.002 (-0.004, 0)	0.05	0.30
cg02931604	6	DPPA5	TSS1500	-0.003 (-0.005, -0.001)	2.5E-03	0.21
cg12757684	6	PLAGL1;HYMAI;PLAGL1	1stExon;Body;5’UTR	0.007 (0.002, 0.011)	1.6E-03	0.21
cg15166039	6			-0.001 (-0.003, 0)	0.05	0.30
cg26873880	6			-0.001 (-0.002, 0)	0.02	0.28
cg10596483	8	JRK	TSS1500	-0.003 (-0.005, -0.001)	0.01	0.25
cg25148117	8	SLCO5A1	Body	-0.002 (-0.004, -0.001)	0.01	0.25
cg13211302	8			0.005 (0.002, 0.008)	2.0E-03	0.21
cg00169964	10	PCDH21	Body	-0.002 (-0.004, 0)	0.01	0.25
cg12353636	10	PCDH21	Body	-0.001 (-0.002, 0)	0.02	0.28
cg20407713	11	DLG2	Body	-0.003 (-0.005, 0)	0.04	0.30
cg04824767	11	FADS3	TSS1500	0.002 (0, 0.004)	0.05	0.30
cg24213572	11	NDUFS8;MIR4691	Body;TSS200	0.009 (0, 0.018)	0.05	0.30
cg14770102	11			0.002 (0, 0.004)	0.02	0.25
cg06026769	12	PDE3A	Body	-0.002 (-0.005, 0)	0.04	0.30
cg25097398	12			-0.002 (-0.004, 0)	0.03	0.29
cg17312277	13			-0.001 (-0.002, 0)	0.03	0.29
cg13713667	14	SPTLC2	Body	0.004 (0.001, 0.008)	0.02	0.28
cg03231735	16	C16orf72	TSS1500	0.002 (0, 0.004)	0.04	0.30
cg04690045	16	LINC00273	TSS1500	-0.005 (-0.01, 0)	0.04	0.30
cg00604771	16			-0.004 (-0.007, -0.001)	0.02	0.28
cg01806526	16			-0.003 (-0.006, 0)	0.02	0.28
cg04478251	17	ABR	Body	0.002 (0, 0.005)	0.02	0.28
cg14057352	17			-0.005 (-0.009, 0)	0.03	0.29
cg26536949	17			-0.001 (-0.002, 0)	0.01	0.25
cg20587168	19	ACTL9	1stExon	-0.004 (-0.008, -0.001)	0.01	0.25
cg15490703	19	EFNA2	Body	0.015 (0.003, 0.026)	0.01	0.25
cg26610167	19	PTPRH;PTPRH	1stExon;5’UTR	-0.001 (-0.002, 0)	0.01	0.25
cg00566515	21	ANKRD20A11P	Body	0.002 (0, 0.004)	0.05	0.30
cg27306467	21	ANKRD20A11P	TSS200	-0.003 (-0.006, 0)	0.04	0.30
cg08447200	22	PANX2	Body	-0.001 (-0.003, 0)	0.04	0.30
CHR: chromosome

Table 3. Placental CpG sites (n = 57) corresponding to metastable epialleles that are associated with BMI z-score across ages one, two, and ten among females

Probe ID	CHR	Gene	Position	β (95% CI)	p	q
cg10386298	1			0.001 (0, 0.002)	0.01	0.07
cg22399133	2	CRYGD;CRYGD	1stExon;5’UTR	0.003 (0.001, 0.005)	1.3E-03	0.02
cg11097064	2	HDAC4	Body	0.004 (0.002, 0.007)	3.3E-04	0.02
cg19633822	2	MGC13005	Body	-0.006 (-0.011, 0)	0.04	0.20
cg07772999	2	PAX8;LOC440839;LOC654433	Body;Body;TSS1	-0.002 (-0.004, 0)	0.02	0.13
cg21550016	2	PAX8;LOC440839;LOC654433	Body;Body;TSS1	-0.002 (-0.003, 0)	0.05	0.21
cg14227325	2	RGPD8	Body	0.001 (0, 0.001)	0.04	0.20
cg12697337	2			-0.001 (-0.003, 0)	0.05	0.20
cg02635726	3			0.002 (0.001, 0.004)	0.01	0.06
cg05467676	3			0.003 (0.001, 0.005)	0.01	0.07
cg18670801	4			-0.004 (-0.007, -0.002)	2.4E-04	0.02
cg16389705	5	CXXC5	5’UTR	0.004 (0.002, 0.006)	1.6E-03	0.02
cg11394785	5	LTC4S	1stExon	0.004 (0.002, 0.006)	5.1E-04	0.02
cg14886255	5	MGAT4B	Body	0.006 (0.003, 0.009)	9.1E-05	0.02
cg04481923	5	MIR886	Body	-0.001 (-0.002, 0)	0.05	0.21
cg24114444	5	NSA2;GFM2	TSS1500;5’UTR	-0.004 (-0.006, -0.001)	1.4E-03	0.02
cg07086918	5	RGS14	TSS200	0.004 (0.001, 0.006)	1.6E-03	0.02
cg15591490	5	RGS14	TSS200	0.002 (0, 0.004)	0.04	0.20
cg06478886	5			-0.002 (-0.003, -0.001)	0.01	0.06
cg11608150	5			-0.001 (-0.003, 0)	0.02	0.10
cg02931604	6	DPPA5	TSS1500	-0.004 (-0.006, -0.002)	6.4E-04	0.02
cg22378065	6	HYMAI;PLAGL1	Body;5’UTR	0.007 (0.001, 0.013)	0.02	0.13
cg15166039	6			-0.003 (-0.005, -0.001)	4.2E-03	0.04
cg23525438	6			0.002 (0, 0.003)	0.01	0.06
cg09652312	7			0.005 (0, 0.009)	0.03	0.14
cg10596483	8	JRK	TSS1500	-0.004 (-0.007, -0.002)	6.6E-04	0.02
cg13211302	8			0.007 (0.003, 0.011)	1.8E-04	0.02
cg05963597	9	PTGDS	TSS1500	0.008 (0.002, 0.013)	0.01	0.06
cg26963250	9			-0.009 (-0.018, -0.001)	0.03	0.15
cg16928034	10	CDHR1	Body	-0.003 (-0.005, -0.001)	1.4E-03	0.02
cg13904877	10	LOC619207	Body	-0.002 (-0.004, 0)	0.03	0.14
cg16807687	10	PCDH21	Body	-0.006 (-0.009, -0.002)	6.1E-04	0.02
cg02276826	10			-0.002 (-0.003, 0)	0.03	0.14
cg11007110	10			-0.002 (-0.004, 0)	0.03	0.14
cg00685014	11	AHNAK	Body	0.003 (0.001, 0.005)	9.0E-04	0.02
cg12857638	11	AHNAK	Body	0.003 (0.001, 0.004)	1.7E-03	0.02
cg04824767	11	FADS3	TSS1500	0.003 (0.001, 0.006)	0.01	0.07
cg13371577	11	FADS3	TSS1500	0.005 (0.001, 0.009)	0.03	0.14
cg15361450	11	FADS3	TSS1500	0.003 (0.001, 0.006)	0.01	0.07
cg14770102	11			0.003 (0.001, 0.005)	1.4E-03	0.02
cg04462774	12	AQP6	Body	-0.003 (-0.005, -0.002)	2.9E-04	0.02
cg24598712	12	FBRSL1	Body	0.008 (0.003, 0.014)	3.6E-03	0.04
cg17181255	12	PLEKHG6;PLEKHG6	TSS1500;TSS200	-0.003 (-0.005, -0.001)	7.3E-04	0.02
cg24333145	12	PLEKHG6;PLEKHG6	TSS1500;TSS200	-0.004 (-0.006, -0.001)	1.4E-03	0.02
cg17312277	13			-0.001 (-0.002, 0)	0.04	0.20
cg13713667	14	SPTLC2	Body	0.005 (0.002, 0.009)	3.5E-03	0.04
cg03231735	16	C16orf72	TSS1500	0.003 (0.001, 0.006)	0.01	0.07
cg03972466	16	C16orf72	TSS1500	0.003 (0, 0.006)	0.02	0.13
cg04834608	16	DNASE1	Body	-0.005 (-0.008, -0.002)	1.4E-03	0.02
cg00604771	16			-0.004 (-0.007, -0.001)	3.7E-03	0.04
cg02459090	16			-0.002 (-0.003, 0)	0.02	0.09
cg04478251	17	ABR	Body	0.004 (0.002, 0.006)	6.0E-04	0.02
cg09925620	17	ASPSCR1	Body	-0.002 (-0.003, 0)	0.02	0.11
cg08110785	17	CUEDC1	Body	0.003 (0.001, 0.005)	0.01	0.06
cg20587168	19	ACTL9	1stExon	-0.006 (-0.01, -0.002)	0.01	0.05
cg25292358	21	ANKRD20A11P	Body	0.007 (0.002, 0.012)	3.0E-03	0.03
cg08447200	22	PANX2	Body	-0.002 (-0.004, 0)	0.01	0.07
CHR: chromosome

Table 4. Placental CpG sites (n = 35) corresponding to metastable epialleles that are associated with BMI z-score across ages one, two, and ten among males

CG	CHR	Gene	Position	β (95% CI)	p	q
cg12080791	1	PMF1	Body	0.02 (0.002, 0.037)	0.03	0.31
cg10553204	2	GDF7	3’UTR	-0.004 (-0.006, -0.001)	0.01	0.22
cg20434511	2	HDAC4	Body	-0.004 (-0.008, 0)	0.04	0.31
cg07772999	2	PAX8;LOC440839;LOC654433	Body;Body;TSS1	0.002 (0, 0.004)	0.03	0.31
cg11763394	2	PAX8;LOC440839;LOC654434	Body;Body;TSS2	0.002 (0, 0.004)	0.03	0.31
cg21482265	2	PAX8;LOC440839;LOC654435	Body;Body;TSS3	0.003 (0, 0.005)	0.04	0.31
cg21550016	2	PAX8;LOC440839;LOC654436	Body;Body;TSS4	0.002 (0, 0.004)	0.03	0.31
cg01101448	2			0.006 (0.002, 0.01)	0.01	0.22
cg25433157	2			-0.008 (-0.014, -0.002)	0.01	0.22
cg17894318	3	SOX2OT	Body	-0.002 (-0.004, -0.001)	0.01	0.22
cg02447542	3			-0.003 (-0.004, -0.001)	2.8E-04	0.03
cg04492927	5	BTNL9	Body	-0.004 (-0.007, 0)	0.03	0.31
cg12757684	6	PLAGL1;HYMAI;PLAGL1	1stExon;Body;5’UTR	0.012 (0.006, 0.018)	1.1E-04	0.03
cg17228698	7	CHST12	5’UTR	-0.004 (-0.007, 0)	0.04	0.31
cg27643890	7	ELFN1	5’UTR	-0.004 (-0.007, -0.001)	0.02	0.30
cg09652312	7			-0.006 (-0.012, 0)	0.04	0.31
cg25148117	8	SLCO5A1	Body	-0.003 (-0.005, 0)	0.04	0.31
cg03128011	8			-0.002 (-0.003, 0)	0.04	0.31
cg00169964	10	PCDH21	Body	-0.003 (-0.006, -0.001)	0.01	0.22
cg00797058	10			-0.004 (-0.007, 0)	0.03	0.31
cg00685014	11	AHNAK	Body	-0.003 (-0.005, 0)	0.02	0.30
cg12857638	11	AHNAK	Body	-0.002 (-0.004, 0)	0.03	0.31
cg13906860	11			-0.002 (-0.005, 0)	0.03	0.31
cg01806526	16			-0.005 (-0.009, -0.001)	0.01	0.28
cg09925620	17	ASPSCR1	Body	0.002 (0.001, 0.004)	0.01	0.22
cg14057352	17			-0.006 (-0.012, 0)	0.05	0.35
cg16081388	17			-0.004 (-0.007, 0)	0.04	0.31
cg21473235	17			0.004 (0.001, 0.006)	0.02	0.30
cg26536949	17			-0.001 (-0.002, 0)	0.01	0.22
cg15490703	19	EFNA2	Body	0.026 (0.009, 0.043)	2.3E-03	0.19
cg26610167	19	PTPRH;PTPRH	1stExon;5’UTR	-0.002 (-0.003, 0)	0.02	0.30
cg11324748	21	ANKRD20A11P	Body	-0.014 (-0.026, -0.003)	0.02	0.30
cg25292358	21	ANKRD20A11P	Body	-0.007 (-0.012, -0.001)	0.02	0.30
cg27306467	21	ANKRD20A11P	TSS200	-0.005 (-0.01, -0.001)	0.03	0.31
cg10346077	X			-0.003 (-0.006, 0)	0.04	0.31
CHR: chromosome

Authors: Jeliyah Clark, Elizabeth Martin, Catherine M. Bulka, Lisa Smeester, Hudson P. Santos, Jr., T. Michael O’Shea, Rebecca C. Fry

Journal: Epigenetics

Bibliometrics: Volume 14, Number 11, pages 1102- 1111

DOI: http://dx.doi.org/10.1080/15592294.2019.1633865

It has come to the attention of the authors that an error occurred during sample processing which influenced results from the article originally published online. Placental DNA samples on a 96-well plate were misoriented to their matching barcodes. This resulted in a mismatch between methylation and clinical data. Once correctly aligned, a small number of samples were identified for which reported infant sex and methylation-predicted sex (using the minfi R package) differed. Correction for these errors resulted in changes in demographic distributions, beta-estimates, p-values, and the CpG probes identified as significant.

The data were re-analyzed, accordingly. The correction of the sample processing error influenced study subject inclusion, decreasing the sample size from n=426 to n=411. Five observations were excluded with a sex mismatch, and 10 additional observations were excluded due to missingness of data required to link samples to phenotype data. In the prior analysis, one CpG site was identified to be differentially methylated among girls (q < 0.05) at PLAGL1. Upon re-analysis, this association was not conserved among females but was identified among males. Specifically, an additional 28 FDR-significant associations were identified in sex-stratified analyses: two among males and 26 among females. Here, we provide corrected tables corresponding to these results. The authors apologize for this error.