ABSTRACT
A group of noroxymorphone derivatives were subjected to Gewald reaction conditions to prepare their respective aminothieno products. In refluxing piperidine/ethanol, 1a–g reacted with elemental sulfur and malononitrile to produce 2a–g in high yields. Reactions took place in one pot and completed within 4–7 h and products precipitated spontaneously in the reaction mixtures.
GRAPHICAL ABSTRACT
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Acknowledgement
S. B. would like to thank TEMAD Pharmaceutical Company for providing some of the required chemicals.
Disclosure statement
No potential conflict of interest was reported by the author(s).
ORCID
Mohammad M. Mojtahedi http://orcid.org/0000-0002-0452-590X