A comprehensive review of the application of 3D-bioprinting in chronic wound management

ABSTRACT

Introduction

Chronic wounds require more sophisticated care than standard wound care because they are becoming more severe as a result of diseases like diabetes. By resolving shortcomings in existing methods, 3D-bioprinting offers a viable path toward personalized, mechanically strong, and cell-stimulating wound dressings.

Areas Covered

This review highlights the drawbacks of traditional approaches while navigating the difficulties of managing chronic wounds. The conversation revolves around employing natural biomaterials for customized dressings, with a particular emphasis on 3D-bioprinting. A thorough understanding of the uses of 3D-printed dressings in a range of chronic wound scenarios is provided by insights into recent research and patents.

Expert Opinion

The expert view recognizes wounds as a historical human ailment and emphasizes the growing difficulties and expenses related to wound treatment. The expert acknowledges that 3D printing is revolutionary, but also points out that it is still in its infancy and has the potential to enhance mass production rather than replace it. The review highlights the benefits of 3D printing for wound dressings by providing instances of smart materials that improve treatment results by stimulating angiogenesis, reducing pain, and targeting particular enzymes. The expert advises taking action to convert the technology’s prospective advantages into real benefits for patients, even in the face of resistance to change in the healthcare industry. It is believed that the increasing evidence from in-vivo studies is promising and represents a positive change in the treatment of chronic wounds toward sophisticated 3D-printed dressings.

KEYWORDS:

• Chronic wounds
• 3D-bioprinting
• wound dressing
• natural biomaterials
• wound

Disclaimer

As a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.

Article Highlights

• 3D printing technology characteristics, components, and materials that are essential for creating constructions for wound healing are covered.

• Chronic wounds need advanced care due to their increasing severity, often worsened by conditions like diabetic foot ulcer, venous ulcer, Pressure ulcer

• 3D-bioprinting emerges as a promising avenue for personalized, robust, and cell-stimulating wound dressings.

• 3D Printed structures having the potential to enhance tailored patient care through increased clinical efficacy

• Highlighting the utilizing of natural biomaterials to craft tailored dressings, with a focus on the potential of 3D-bioprinting.

• Research investigations and patent insights offer a comprehensive understanding of the applications of 3D-printed dressings in advanced wound care

Declaration of interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.