The chemopreventive and anticancer potential against colorectal cancer of polyphenol-rich fruit extracts

ABSTRACT

The consumption of vegetables and fruits, particularly apples, pomegranates, grapes, and berries, is associated with a decreased risk of developing cancer, especially colorectal cancer (CRC). This may be attributable to the presence of phytochemical constituents, such as polyphenols. This review summarizes the current state of knowledge concerning the chemopreventive and anti-CRC potential of polyphenol-rich apple, pomegranate, grape, and berry extracts with a focus on in vitro, in vivo, and clinical evidence. The extracts demonstrate antiproliferative, proapoptotic, antiangiogenic, antiinvasive, and antimetastatic activities toward colon cancer cell lines and in animal models and markedly influence preneoplastic lesions and malignancies in humans.

KEYWORDS:

• Anticancer activities
• chemoprevention
• colorectal cancer
• fruit
• polyphenol-rich extract

Declaration of interest

The authors declare no conflict of interest.

Funding

The study was supported by a grant from the Medical University of Lodz (No 503/1-156-04/503-01).

Additional information

Funding

The study was supported by a grant from the Medical University of Lodz (No 503/1-156-04/503-01).