Aminoglycosides in Food: Recent Updates on the Pretreatment and Analysis Methods

ABSTRACT

Aminoglycosides, as effective, broad-spectrum antibiotics, have been widely used in animal husbandry. These antibiotics can cause potential hazards to human health, as they can accumulate through the food chain. To obtain a better control of food quality and safety, developing effective and sensitive methods for the pretreatment and determination of aminoglycosides is essential. This review aims at elucidating on the health risk-toxicology of aminoglycosides in food and to provide a comprehensive overview of aminoglycosides pretreatment and detection methods since 2010. Moreover, novel pretreatment methods such as microextraction, QuEChERS and online technology as well as novel analytic methods such as orbitrap MS, are summarized. Furthermore, we elaborate and compare the merits and demerits of diverse pretreatment and analytical methods and suggest their future prospects.

KEYWORDS:

• Aminoglycosides
• pretreatment
• analytical methods
• food safety
• update

Highlights

1. Health risk of aminoglycosides in food were elucidated.

2. Microextraction technology was one of the trends of aminoglycosides pretreatment in the future.

3. Applications of novel materials in SPE were highlighted.

4. High resolution mass spectrometry was accurate and sensitive with great potential.

Abbreviation

ACN, acetonitrile; AGs, aminoglycosides; AMK, amikacin; APCI, Atmospheric pressure chemical ionization; APM, apramycin; ASE, accelerated solvent extraction; BIA, batch-injection analysis; CCD, Contactless conductivity detection; C⁴D, Capacitively Coupled Contactless Conductivity Detection; CE, capillary electrophoresis; DAD, diode array detector; DHS, dihydrostreptomycin; DLLME, dispersive liquid-liquid micro extraction; EDTA, ethylene diamine tetra acetate; ELISA, enzyme-linked immunosorbent assay; ELSD, evaporative light scattering detector; ESI, electrospray ionization; ETM, etimicin; FAM, farmiglucin; FASS, field-amplified sample stacking; FLD, fluorescence detector; FPIA, fluorescence polarization immunoassay; GCE, glassy carbon electrode; GENT, gentamicin; GNPs, gold nanoparticles; HILIC, hydrophilic interaction chromatography; HFBA, heptafluorobutyric acid; HPLC, high-performance liquid chromatography; HRMS, high-resolution MS; HYGR, hygromycin B; IC₅₀, half-maximum inhibition concentration; IcELISA, indirect competitive enzyme-linked immunosorbent assay; ILs, ionic liquids; IPC, ion-pair chromatography; ISM, isepamicin; IST, istamycin; KAM, kanamycin; KASU, kasugamycin; LC, liquid chromatography; LLE, liquid–liquid extraction; LOD, limit of detection; LOQ, limit of qualification; MAE, microwave-assisted extraction; MIP, molecularly imprinted polymer; ME, matrix effects; MeOH, methanol; MMF-SPME, multiple monolithic fiber solid-phase microextraction; MMSPD, mixed matrix solid-phase dispersion; MRLs, maximum residue limits; MRM, multiple-response monitoring; MS, mass spectrometry; MSPD, matrix solid-phase dispersion; MSPE, magnetic solid-phase extraction; NEO, neomycin; NIPs, nonimprinted polymers; NTL, netilmicin; PFE, pressurized fluid extraction; PFPA, pentafluoropropionic acid; PLE, pressurized liquid extraction; PPy, polypyrrole; PRM, paromomycin; QQQ, triple-quadrupole instrument; QuEChERS, quick easy cheap effective rugged safety; RIBO, ribostamycin; RSD, Relative standard deviation; SISO, sisomicin; SPC, spectinomycin; SPE, solid-phase extraction; SPME, solid-phase micro extraction; STP, streptomycin; TCA, trichloroacetic acid; TDM, therapeutic drug monitoring; TOB, tobramycin; TOF, time of flight; UAE, ultrasound-assisted extraction; UF, urea-formaldehyde; UHPLC, ultrahigh-performance liquid chromatography; VAL-A, validamycin-A; WCX, weak cation exchange; ZIC, zwitterionic stationary phases.

Acknowledgments

This work was supported by Scientific Research Project of Department of Education of Liaoning Province (NO. ZF2019036); Key Program of the Natural Science Foundation of Liaoning Province of China (NO. 20170541027) and Liaoning planning Program of philosophy and social science (NO. L17BGL034).

Conflicts of interest

There are no conflicts to declare.

Additional information

Funding

This work was supported by the Liaoning planning Program of philosophy and social science [NO. L17BGL034]; Key Program of the Natural Science Foundation of Liaoning Province of China [NO. 20170541027]; Scientific Research Project of Department of Education of Liaoning Province [NO. ZF2019036].