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Pharmaceutical Development and Technology Volume 8, 2003 - Issue 4
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Technical Note

Design of Experiment (DOE) Methods Maximize Information from a Minimal Number of Animals in Special Cases of Preclinical Bioavailability Testing

Dr. Martin Kuentz Pharmaceutical and Analytical R&D, Pharma, PRNF, F.Hoffmann‐La Roche Ltd., Bldg. 072/338, CH‐ 4070, Basel, Switzerland
,
Dieter Röthlisberger Pharmaceutical and Analytical R&D, Pharma, PRNF, F.Hoffmann‐La Roche Ltd., Bldg. 072/338, CH‐ 4070, Basel, Switzerland
&
Wolfgang Richter Pharma, PRNS, F.Hoffmann‐La Roche Ltd., Bldg. 072/338, CH‐ 4070, Basel, Switzerland
Pages 453-458 | Received 22 Nov 2002, Accepted 24 Mar 2003, Published online: 18 Sep 2003
 
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