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Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC50=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC50=68 μM) and prostate cancer LNCaP cells (IC50=193 μM). Millet containing linoleic acid might have anti-tumor activity.
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