The role of urokinase in idiopathic pulmonary fibrosis and implication for therapy

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and frequently fatal form of interstitial lung disease for which there are no proven drug therapies. The pathogenesis of IPF is complex and the urokinase-type plasminogen activator (uPA)/plasminogen system participates in the repair process. The balance between the activating enzyme uPA, and its inhibitor PAI-1, is a critical determinant of the amount of scar development that follows. Objective: To address the role of urokinase in the pathogenesis of pulmonary fibrosis and its implications for therapy. Methods: We reviewed a spectrum of therapeutic strategies and focused on fibrinolytic and anticoagulant drugs for IPF patients. Results/conclusion: There is currently a search for new pharmacotherapeutic agents that may modulate the fibrogenic pathways in IPF. Either blocking PAI-1 or using uPA itself may be a promising new therapeutic strategy.

Keywords::

• antifibrotic agents
• fibrosis
• hepatocyte growth factor
• inflammation
• lung
• myofibroblasts
• pathogenesis
• plasminogen activator inhibitor
• repair
• tissue plasminogen activator
• treatment
• urokinase plasminogen activator

Notes