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Review

Heat-shock proteins: new keys to the development of cytoprotective therapies

, &
Pages 759-769 | Published online: 18 Sep 2006
 

Abstract

As molecular chaperones, heat-shock proteins (HSPs) function to limit protein aggregation, facilitate protein refolding and chaperone other proteins. Under conditions of cellular stress, intracellular HSP levels increase in order to provide cellular protection and maintain homeostasis. Evidence exists that the HSP family may be secreted into the circulation via lipid raft-mediated, granule-mediated or exosome-mediated exocytosis in haematopoietic and tumour cells. Extracellular HSPs exert immunomodulatory activities and play an important role in innate immune activation against pathogen infection. Membrane-bound Hsp70 in tumour cells or released chaperone-tumour associated antigen complex represent a target structure for the cytolytic attack by natural killer cells or T lymphocytes. Cellular stresses induce stress granule formation to evade detrimental cellular effects, mediating preconditioning phenotype. Therefore, induction of cellular stress tolerance by preconditioning (e.g., heat shock) might be potential therapeutic targets.

Addendum

During preparation of this revision, a very interesting paper on the stress response of cancer cells has been published Citation[87]. The authors demonstrated that behavioural stress induces tissue catecholamine production, which is responsible for the tumour growth and invasion using ovarian cancer model in vivo. Through the β-adrenergic receptor-cAMP-PKA pathway, tumour cells increased the expression of VEGF and MMPs, key factors for angiogenesis. This paper provides evidence that links stress responses to neuroendocrine signalling in cancer, supports the possible roles of hormones in stress responses in normal Citation[26] and pathological state.

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