Abstract
Background: Chip-based bioanalytical methods represent a promising approach for a highly parallel and robust analysis with minimal sample volumes. Key process parameters that can be decisive for certain applications are determined by the detection scheme utilized. Objective: This review addresses typical requirements of chip-based detection systems, especially for the emerging field of point-of-care diagnostics that make possible field detection with less-trained personnel, robust assays as well as low instrumentation costs. Methods: The use of metal nanoparticles as labels represents a promising approach. They exhibit a high stability in signal and new detection schemes that would allow for robustness and low-cost readout. Results/conclusion: First examples of this kind have been established and are in the market, and more are in the development pipeline.