Abstract
Oral drug administration can be problematic owing to the specific physicochemical characteristics of new chemical entities. Assessment of the possibility of a new active compound to be administered orally, as well as of the requirements for a successful oral administration (type of dosage form, dosing conditions), constitute a substantial burden during the drug-discovery and drug-development process. Throughout drug development, in silico, in vitro, in vivo and integrated dynamic models play an important role for the decision making in absorption-related issues. In this review, the most common methods used for the prediction of oral drug absorption as a stage development approach are discussed.
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.